Bionic tissue engineering of peripheral nerves and progress in neuroregeneration

IF 13.2 1区工程技术 Q1 ENGINEERING, CHEMICAL

Chemical Engineering Journal Pub Date : 2025-03-29 DOI:10.1016/j.cej.2025.162123

Dian Jiao , Yumin Yang , Panjian Lu , Xiaosong Gu , Dong Ming

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引用次数: 0

Abstract

Peripheral nerve injury (PNI) significantly impairs patient function and quality of life, necessitating effective therapeutic interventions. Traditional surgical sutures and autologous nerve grafts have limitations or undesirable consequences such as scarring, inflammation, and donor site morbidity. Tissue-engineered nerve grafts (TENG) offer a promising approach by providing a structured environment for axon regeneration. However, there are challenges in the application of TENGs such as material stiffness and the need for a more natural regenerative microenvironment. Bionic TENGs are an innovative approach that uses cellular matrices and a well-controlled microenvironment to improve the efficiency and effectiveness of neuroregeneration. This review summarizes recent advances in materials science and biotechnology that have enabled the development of TENGs, describes strategies to optimize the microenvironment for neuroregeneration, and explores the future of functional restoration. This review explores the integration of novel materials and technologies to address current challenges and highlights the clinical potential of regenerative medicine for PNI treatment.

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周围神经仿生组织工程及其再生研究进展

周围神经损伤（PNI）显著损害患者的功能和生活质量，需要有效的治疗干预。传统的手术缝合和自体神经移植有局限性或不良后果，如疤痕、炎症和供区发病率。组织工程神经移植为轴突再生提供了一个结构化的环境，是一种很有前途的方法。然而，在应用中存在着诸如材料刚度和对更自然的再生微环境的需求等挑战。仿生teng是一种利用细胞基质和良好控制的微环境来提高神经再生效率和效果的创新方法。本文综述了材料科学和生物技术的最新进展，这些进展促进了神经再生的发展，描述了优化神经再生微环境的策略，并探讨了功能修复的未来。这篇综述探讨了新材料和新技术的整合，以解决当前的挑战，并强调了再生医学治疗PNI的临床潜力。

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来源期刊

Chemical Engineering Journal 工程技术-工程：化工

CiteScore

21.70

自引率

9.30%

发文量

6781

审稿时长

2.4 months

期刊介绍： The Chemical Engineering Journal is an international research journal that invites contributions of original and novel fundamental research. It aims to provide an international platform for presenting original fundamental research, interpretative reviews, and discussions on new developments in chemical engineering. The journal welcomes papers that describe novel theory and its practical application, as well as those that demonstrate the transfer of techniques from other disciplines. It also welcomes reports on carefully conducted experimental work that is soundly interpreted. The main focus of the journal is on original and rigorous research results that have broad significance. The Catalysis section within the Chemical Engineering Journal focuses specifically on Experimental and Theoretical studies in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. These studies have industrial impact on various sectors such as chemicals, energy, materials, foods, healthcare, and environmental protection.