Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy.

Photodiagnosis and photodynamic therapy Pub Date : 2025-03-24 DOI:10.1016/j.pdpdt.2025.104567

N Bridged Magaela, Muthumuni Managa, Tebello Nyokong

引用次数: 0

Abstract

Novel 4- (5,10,15)-tris-boronphenyl-20- (4-formylphenoxy) porphyrin (complex 1) and its Zn-metalated derivative (complex 2) were synthesized and conjugated to bismuth doped carbon nanospheres (BiCNS) through non-covalent bonds (π-π). The conjugation of BiCNS to porphyrin complexes enhanced the singlet oxygen production of porphyrin complexes, as it was observed that porphyrin complex 1 gave a singlet oxygen quantum yield (Φ_∆) value of 0.17 and complex 2 gave Φ_∆ of 0.23, and upon conjugation with BiCNS the Ф_∆ values increased to 0.52 and 0.67, respectively. Photodynamic therapy (PDT) studies were performed against MDA-MB-231 breast cancer cell line using these complexes and their conjugates and it was observed that BiCNS conjugates resulted in enhanced PDT activity when compared to CNS conjugates. Conjugates 2-CNS, and 2-BiCNS at the concentration of 100 µg/mL they resulted with cell viabilities of 28.43 and 26.82%, respectively.

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掺铋碳纳米球与硼化卟啉共轭用于光动力疗法。

合成了新型 4- (5,10,15)-tris-boronphenyl-20- (4-formylphenoxy)卟啉（络合物 1）及其 Zn 金属化衍生物（络合物 2），并通过非共价键（π-π）与掺铋碳纳米球（BiCNS）共轭。将 BiCNS 与卟啉复合物共轭可提高卟啉复合物的单线态氧产生量，据观察，卟啉复合物 1 的单线态氧量子产率（Φ∆）值为 0.17，复合物 2 的 Φ∆ 值为 0.23，而与 BiCNS 共轭后，Ф∆ 值分别增至 0.52 和 0.67。使用这些复合物及其共轭物对 MDA-MB-231 乳腺癌细胞系进行了光动力疗法（PDT）研究，结果表明，与 CNS 共轭物相比，BiCNS 共轭物的光动力疗法活性更强。浓度为 100 µg/mL 的 2-CNS 和 2-BiCNS 结合物的细胞活力分别为 28.43% 和 26.82%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Photodiagnosis and photodynamic therapy

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