Bismuth doped carbon nanospheres conjugated to boronated porphyrins for photodynamic therapy

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-03-24 DOI:10.1016/j.pdpdt.2025.104567

N․Bridged Magaela , Muthumuni Managa , Tebello Nyokong

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Abstract

Novel 4- (5,10,15)-tris-boronphenyl-20-(4-formylphenoxy) porphyrin (complex 1) and its Zn-metalated derivative (complex 2) were synthesized and conjugated to bismuth doped carbon nanospheres (BiCNS) through non-covalent bonds (

π - π)

. The conjugation of BiCNS to porphyrin complexes enhanced the singlet oxygen production of porphyrin complexes, as it was observed that porphyrin complex 1 gave a singlet oxygen quantum yield (Φ_∆) value of 0.17 and complex 2 gave Φ_∆ of 0.23, and upon conjugation with BiCNS the Ф_∆ values increased to 0.52 and 0.67, respectively. Photodynamic therapy (PDT) studies were performed against MDA-MB-231 breast cancer cell line using these complexes and their conjugates and it was observed that BiCNS conjugates resulted in enhanced PDT activity when compared to CNS conjugates. Conjugates 2-CNS, and 2-BiCNS at the concentration of 100 µg/mL they resulted with cell viabilities of 28.43 and 26.82 %, respectively.

Abstract Image

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掺铋碳纳米球与硼化卟啉共轭用于光动力疗法。

合成了新型 4- (5,10,15)-tris-boronphenyl-20- (4-formylphenoxy)卟啉（络合物 1）及其 Zn 金属化衍生物（络合物 2），并通过非共价键（π-π）与掺铋碳纳米球（BiCNS）共轭。将 BiCNS 与卟啉复合物共轭可提高卟啉复合物的单线态氧产生量，据观察，卟啉复合物 1 的单线态氧量子产率（Φ∆）值为 0.17，复合物 2 的 Φ∆ 值为 0.23，而与 BiCNS 共轭后，Ф∆ 值分别增至 0.52 和 0.67。使用这些复合物及其共轭物对 MDA-MB-231 乳腺癌细胞系进行了光动力疗法（PDT）研究，结果表明，与 CNS 共轭物相比，BiCNS 共轭物的光动力疗法活性更强。浓度为 100 µg/mL 的 2-CNS 和 2-BiCNS 结合物的细胞活力分别为 28.43% 和 26.82%。

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.