{"title":"Echocardiography myocardial work assessment of chemotherapy-induced cardiotoxicity: a systematic review and meta-analysis.","authors":"Guyue Liu, Zhiyue Liu, Mingjian Lang","doi":"10.11152/mu-4502","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>The objective was to assess chemotherapy-induced cardiotoxicity by comparing changes in myocardial work indices (MWI) using echocardiographic myocardial work (MW).</p><p><strong>Material and method: </strong>A comprehensive search was performed in PubMed, Embase, and the Cochrane Library, covering literature up to June 2024.</p><p><strong>Results: </strong>A total of 13 non-randomized experimental studies (n=1,373) assessed changes in MWI of cancer patients treated with anthracyclines, trastuzumab/pertuzumab, or immune checkpoint inhibitors. After chemotherapy, adecrease was observed in the left ventricular ejection fraction (LVEF) (Pooled standard mean difference [SMD] = -0.75, 95% CI: -1.18, -0.31, p=0.001, I 2= 95.9%), global longitudinal strain (GLS) (Pooled SMD = -2.38, 95% CI: -3.10, -1.66, p<0.001, I 2= 97.9%), global work index (Pooled SMD = -1.27, 95% CI: -1.68, -0.86, p<0.001, I2= 95.0%), global constructive work (GCW) (Pooled SMD = -1.55, 95% CI: -2.10, -0.99, p<0.001, I 2= 96.9%), and global work efficiency (Pooled SMD = -1.66, 95% CI: -2.39, -0.94, p<0.001, I2= 98.2%). Conversely, global wasted work (GWW) increased (Pooled SMD = 1.17, 95% CI: 0.44, 1.89, p=0.002, I 2= 98.2%). Post-chemotherapy, GCW and GLS were below normal ranges, GWW exceeded normal values, and LVEF remained within normal limits across all subgroups.</p><p><strong>Conclusions: </strong>Echocardiographic MWI provides a non-invasive method for assessing cardiotoxicity induced by anthracyclines, trastuzumab / pertuzumab, or immune checkpoint inhibitors.</p>","PeriodicalId":94138,"journal":{"name":"Medical ultrasonography","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical ultrasonography","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11152/mu-4502","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: The objective was to assess chemotherapy-induced cardiotoxicity by comparing changes in myocardial work indices (MWI) using echocardiographic myocardial work (MW).
Material and method: A comprehensive search was performed in PubMed, Embase, and the Cochrane Library, covering literature up to June 2024.
Results: A total of 13 non-randomized experimental studies (n=1,373) assessed changes in MWI of cancer patients treated with anthracyclines, trastuzumab/pertuzumab, or immune checkpoint inhibitors. After chemotherapy, adecrease was observed in the left ventricular ejection fraction (LVEF) (Pooled standard mean difference [SMD] = -0.75, 95% CI: -1.18, -0.31, p=0.001, I 2= 95.9%), global longitudinal strain (GLS) (Pooled SMD = -2.38, 95% CI: -3.10, -1.66, p<0.001, I 2= 97.9%), global work index (Pooled SMD = -1.27, 95% CI: -1.68, -0.86, p<0.001, I2= 95.0%), global constructive work (GCW) (Pooled SMD = -1.55, 95% CI: -2.10, -0.99, p<0.001, I 2= 96.9%), and global work efficiency (Pooled SMD = -1.66, 95% CI: -2.39, -0.94, p<0.001, I2= 98.2%). Conversely, global wasted work (GWW) increased (Pooled SMD = 1.17, 95% CI: 0.44, 1.89, p=0.002, I 2= 98.2%). Post-chemotherapy, GCW and GLS were below normal ranges, GWW exceeded normal values, and LVEF remained within normal limits across all subgroups.
Conclusions: Echocardiographic MWI provides a non-invasive method for assessing cardiotoxicity induced by anthracyclines, trastuzumab / pertuzumab, or immune checkpoint inhibitors.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
