Aquaporins: Bridging Normal Brain Development and Neurodevelopmental Disorder Mechanisms.

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neuroscience Pub Date : 2025-03-26 DOI:10.1159/000545512

Fateme Azizi, Wing Ki Chan, Maryam Ardalan

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Abstract

Background: Homeostasis of water content in the brain during fetal development is of crucial physiological importance. Aquaporins (AQPs) play a critical role in maintaining brain water balance, supporting normal brain development, and are increasingly recognized for their relevance in understanding neurodevelopmental disorders.

Summary: This review provides a comprehensive overview of AQPs and their essential roles in the central nervous system (CNS), specifically AQP4, AQP11, and AQP9, which play a crucial role in water transport in the brain, maintaining water homeostasis and facilitating water movement across cell membranes. The review also highlights how disruptions in AQP expression and function may contribute to the pathology of neurodevelopmental disorders such as autism and Fragile X syndrome.

Key messages: AQPs are vital for brain water regulation and normal neural development. Altered expression or function of AQPs can impact blood-brain barrier integrity, neuroinflammation, and synaptic activity. AQP dysfunctions are linked to neurodevelopmental disorders and may represent promising therapeutic targets.

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水通道蛋白：连接正常大脑发育和神经发育障碍机制。

胎儿发育过程中大脑含水量的平衡具有重要的生理意义。水蒸发素在大脑水分平衡和大脑正常发育中发挥着关键作用，对了解和治疗神经发育疾病具有重要意义。在这篇综述中，我们全面概述了水汽素（AQPs）及其在中枢神经系统（CNS）和各种神经发育疾病中的关键作用。具体而言，AQP4、AQP11 和 AQP9 在大脑的水分运输、维持水分平衡以及促进水分在细胞膜上的移动方面发挥着至关重要的作用。这篇综述强调了水通道蛋白表达和功能的紊乱如何可能导致各种神经发育障碍，包括自闭症和脆性 X 综合征。这些干扰会影响血脑屏障的完整性、神经炎症和突触功能，表明水通道蛋白可能是这些疾病的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.