{"title":"Aquaporins: Bridging Normal Brain Development and Neurodevelopmental Disorder Mechanisms.","authors":"Fateme Azizi, Wing Ki Chan, Maryam Ardalan","doi":"10.1159/000545512","DOIUrl":null,"url":null,"abstract":"<p><p>Homeostasis of water content in the brain during fetal development is of crucial physiological importance. Aquaporins play a critical role in brain water homeostasis, and normal brain development, and have implications for understanding and potentially treating neurodevelopmental disorders. In this review, we provide a comprehensive overview of aquaporins (AQPs) and their critical roles in the central nervous system (CNS) and various neurodevelopmental disorders. Specifically, AQP4, AQP11 and AQP9 play a crucial role in water transport in the brain, maintaining water homeostasis, and facilitating water movement across cell membranes. The review highlights how disruptions in aquaporin expression and function may contribute to various neurodevelopmental disorders, including autism and Fragile X syndrome. These disruptions can affect blood-brain barrier integrity, neuroinflammation, and synaptic function, suggesting that AQPs could be potential therapeutic targets for these conditions.</p>","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"1-19"},"PeriodicalIF":2.3000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545512","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Homeostasis of water content in the brain during fetal development is of crucial physiological importance. Aquaporins play a critical role in brain water homeostasis, and normal brain development, and have implications for understanding and potentially treating neurodevelopmental disorders. In this review, we provide a comprehensive overview of aquaporins (AQPs) and their critical roles in the central nervous system (CNS) and various neurodevelopmental disorders. Specifically, AQP4, AQP11 and AQP9 play a crucial role in water transport in the brain, maintaining water homeostasis, and facilitating water movement across cell membranes. The review highlights how disruptions in aquaporin expression and function may contribute to various neurodevelopmental disorders, including autism and Fragile X syndrome. These disruptions can affect blood-brain barrier integrity, neuroinflammation, and synaptic function, suggesting that AQPs could be potential therapeutic targets for these conditions.
期刊介绍：
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.
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