Sunder Gidumal, Diana Kirke, Benjamin Laitman, Sarah K Rapoport, Peak Woo
{"title":"Nanofat for Injection Laryngoplasty: A Preliminary Study of a New Substrate.","authors":"Sunder Gidumal, Diana Kirke, Benjamin Laitman, Sarah K Rapoport, Peak Woo","doi":"10.1016/j.jvoice.2025.02.007","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>\"Nanofat\" refers to fat further emulsified into 1-µm sizes. It is commonly used in facial plastic surgery. Nanofat increases the release of adipose-derived stem cells. This study tested whether injection laryngoplasty using nanofat resulted in bulking and vibratory effects comparable to using microfat in treating patients with fold atrophy.</p><p><strong>Methods: </strong>This was a randomized, controlled, single-blind, prospective study of 18 patients with vocal atrophy who underwent transoral lipoinjection using microlaryngoscopy. The control group received bilateral microfat injection. The experimental group randomly received microfat in one vocal fold and nanofat in the contralateral vocal fold. The average volume of fat injected was 0.6 mL on each side. The postsurgery evaluation at 3 months included ratings of stroboscopy and acoustic recordings by blinded expert raters. Vibratory behavior, voice ratings, preVoice Handicap Index-10 (VHI-10) and postVHI-10 score, and Cepstral/Spectral Index of Dysphonia (CSID) were compared.</p><p><strong>Results: </strong>Significant improvement in the VHI at three-month follow-up was noted in all patients (n = 18 total, 12 experimental, six control). In the subgroup analysis, only the nanofat group significantly improved VHI. Improvements in the CSID were observed in both techniques; however, neither group showed statistical significance. Improved glottic closure was comparable in both groups. Expert raters observed an improvement in the voice quality of nanofat individuals but no change in microfat individuals.</p><p><strong>Conclusion: </strong>Lipoinjection laryngoplasty with nanofat may be an alternative to microfat in patients with vocal atrophy.</p><p><strong>Level of evidence: </strong>II.</p>","PeriodicalId":49954,"journal":{"name":"Journal of Voice","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Voice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jvoice.2025.02.007","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: "Nanofat" refers to fat further emulsified into 1-µm sizes. It is commonly used in facial plastic surgery. Nanofat increases the release of adipose-derived stem cells. This study tested whether injection laryngoplasty using nanofat resulted in bulking and vibratory effects comparable to using microfat in treating patients with fold atrophy.
Methods: This was a randomized, controlled, single-blind, prospective study of 18 patients with vocal atrophy who underwent transoral lipoinjection using microlaryngoscopy. The control group received bilateral microfat injection. The experimental group randomly received microfat in one vocal fold and nanofat in the contralateral vocal fold. The average volume of fat injected was 0.6 mL on each side. The postsurgery evaluation at 3 months included ratings of stroboscopy and acoustic recordings by blinded expert raters. Vibratory behavior, voice ratings, preVoice Handicap Index-10 (VHI-10) and postVHI-10 score, and Cepstral/Spectral Index of Dysphonia (CSID) were compared.
Results: Significant improvement in the VHI at three-month follow-up was noted in all patients (n = 18 total, 12 experimental, six control). In the subgroup analysis, only the nanofat group significantly improved VHI. Improvements in the CSID were observed in both techniques; however, neither group showed statistical significance. Improved glottic closure was comparable in both groups. Expert raters observed an improvement in the voice quality of nanofat individuals but no change in microfat individuals.
Conclusion: Lipoinjection laryngoplasty with nanofat may be an alternative to microfat in patients with vocal atrophy.
期刊介绍：
The Journal of Voice is widely regarded as the world''s premiere journal for voice medicine and research. This peer-reviewed publication is listed in Index Medicus and is indexed by the Institute for Scientific Information. The journal contains articles written by experts throughout the world on all topics in voice sciences, voice medicine and surgery, and speech-language pathologists'' management of voice-related problems. The journal includes clinical articles, clinical research, and laboratory research. Members of the Foundation receive the journal as a benefit of membership.
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