Post-COVID-19 syndrome and low-grade inflammation: exploring gender and occupational inequalities in a retrospective cohort study.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2025-03-26 DOI:10.1093/inthealth/ihaf021

Lin Yanhui, Wang Jiangang, Gao Jianping, Wang Tao

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引用次数: 0

Abstract

Background: To investigate the association between post-coronavirus disease 2019 (COVID-19) syndrome (PCS) and chronic low-grade inflammation (LGI) in blood cells in 4108 mild COVID-19 patients.

Methods: The data were collected within 12-24 weeks before and 24 weeks after COVID-19 infection. The χ2 test was utilized to analyse the differences between two groups. The relationship between PCS symptoms and inflammatory cells was analysed by logistic regression analysis.

Results: The most common PCS symptom was cough, reported as 'occasionally' by 33.47% and 'frequently' by 5.92%. Women exhibited more severe symptoms than men. Among healthcare workers, palpitations were more pronounced (0.76% versus 0.35%), while the prevalence of other PCS symptoms was lower compared with non-healthcare workers. After adjusting for confounding factors, women showed a higher risk of five types of PCS, and healthcare workers had a greater risk of fatigue and dizziness compared with the non-healthcare worker. Fatigue was associated with lymphocytes, monocytes and the neutrophil:lymphocyte ratio (NLR). Cough correlated with high-sensitivity C-reactive protein (hs-CRP), NLR and the platelet:lymphocyte ratio (PLR). Dizziness was linked to hs-CRP, NLR and PLR. Palpitations correlated with hs-CRP.

Conclusions: Our findings suggest that PCS symptoms may be associated with LGI in peripheral blood cells, gender and occupational inequalities, warranting further investigation.

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covid -19后综合征和低度炎症：一项回顾性队列研究探讨性别和职业不平等

背景：探讨4108例轻度COVID-19患者的2019冠状病毒病后综合征（COVID-19）与血细胞慢性低度炎症（LGI）的关系。方法：采集COVID-19感染前12-24周和感染后24周的数据。采用χ2检验分析两组间差异。采用logistic回归分析PCS症状与炎症细胞的关系。结果：咳嗽是最常见的症状，“偶尔”占33.47%，“经常”占5.92%。女性表现出比男性更严重的症状。在医护人员中，心悸更为明显（0.76%对0.35%），而其他PCS症状的患病率低于非医护人员。在调整混杂因素后，女性表现出五种类型PCS的更高风险，卫生保健工作者比非卫生保健工作者有更大的疲劳和头晕风险。疲劳与淋巴细胞、单核细胞和中性粒细胞：淋巴细胞比值（NLR）有关。咳嗽与高敏c反应蛋白（hs-CRP）、NLR、血小板/淋巴细胞比值（PLR）相关。头晕与hs-CRP、NLR和PLR有关。心悸与hs-CRP相关。结论：我们的研究结果表明PCS症状可能与外周血LGI、性别和职业不平等有关，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.