Chemical Risks, Genotoxicity, and Oxidative Stress in Healthcare Workers.

IF 3.9 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Toxics Pub Date : 2025-03-06 DOI:10.3390/toxics13030189

Ayşe Coşkun Beyan, Esra Emerce, Gamze Tuna, Gül Hüray İşlekel

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引用次数: 0

Abstract

Background/Objectives Using genotoxicity tests and oxidative stress indicators, the study evaluated the relationship between healthcare workers' (HCWs) exposure to chemical risks. This study aimed to evaluate the oxidative damage and genotoxic effects of sub chronic or long-term volatile organic compounds (VOCs) exposure in HCWs.

Methods: Pathology workers (Group 1), cleaning workers (Group 2), and medical secretaries (Group 3) were categorized, and VOCs and alkaline dust were measured for Groups 1 and 2 using appropriate occupational hygiene methods. Genotoxicity was assessed using alkaline comet and micronucleus (MN) assays. Oxidative stress indicators were analyzed in first-morning urine samples through liquid chromatography.

Results: A total of 90 HCWs participated in the study. The mean R-cdA levels were 0.05 ± 0.02 for medical secretaries, 0.07 ± 0.03 for cleaning workers, and 0.06 ± 0.07 nmol/mmol creatinine for pathology workers (p = 0.040). The mean tail intensity (%) was 16.33 ± 10.68 (Group 1), 18.9 ± 7.4 for cleaning workers, and 14.1 ± 6.5 for medical secretaries (p = 0.020).

Conclusion: Implementing occupational hygiene measures in the working environment has effectively reduced occupational risks. The lack of significant differences in genotoxicity and oxidative stress parameters between the exposed and control groups supports the notion that the exposure limit values are protective.

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来源期刊

Toxics Chemical Engineering-Chemical Health and Safety

CiteScore

4.50

自引率

10.90%

发文量

681

审稿时长

6 weeks

期刊介绍： Toxics (ISSN 2305-6304) is an international, peer-reviewed, open access journal which provides an advanced forum for studies related to all aspects of toxic chemicals and materials. It publishes reviews, regular research papers, and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in detail. There is, therefore, no restriction on the maximum length of the papers, although authors should write their papers in a clear and concise way. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of calculations and experimental procedure can be deposited as supplementary material, if it is not possible to publish them along with the text.