Evaluation of the mechanical properties and cell cultural behavior of diamond lattice scaffolds with different porosities.

IF 1.7 4区 医学 Q3 ENGINEERING, BIOMEDICAL
Hojjat Ghahramanzadeh Asl, Selcen Çelik Uzuner, Salim Çam, Uğur Uzuner
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引用次数: 0

Abstract

Metal porous structures are a common treatment for bone tissue loss when the loss exceeds the self-repair capacity of the human body. The structural characteristics, mechanical properties, and biological behavior of scaffold biomaterials exert a significant influence on the formation of new bone cells. The objective of this study was to ascertain the mechanical and cell biological behavior of scaffold structures with four distinct porosities (60%, 70%, 80%, and 90%). Scaffold structures with a diamond lattice unit cell were manufactured by the selective laser melting method using a CoCr alloy powder with a diameter of 4 mm and a height of 5 mm and were then subjected to a static compression test. Subsequently, human gingival fibroblast cells were seeded into each sample via the cell culture process, and cell formation was observed. According to the results obtained from the compression test, the sample with 60% porosity demonstrated optimal mechanical performance and effective modulus of elasticity. In the cell culture process, the sample with 60% porosity exhibited the highest adherence rate.

不同孔隙率金刚石晶格支架的力学性能及细胞培养行为评价。
当骨组织丢失超过人体自我修复能力时,金属多孔结构是一种常用的治疗骨组织丢失的方法。支架生物材料的结构特征、力学性能和生物学行为对新骨细胞的形成有重要影响。本研究的目的是确定四种不同孔隙率(60%、70%、80%和90%)的支架结构的力学和细胞生物学行为。采用直径为4 mm、高度为5 mm的CoCr合金粉末,采用选择性激光熔化法制备了具有金刚石晶格单元格的支架结构,并进行了静态压缩试验。随后,通过细胞培养过程将人牙龈成纤维细胞接种到每个样品中,观察细胞形成情况。压缩试验结果表明,孔隙率为60%的试样力学性能和有效弹性模量最佳。在细胞培养过程中,孔隙率为60%的样品黏附率最高。
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来源期刊
CiteScore
3.60
自引率
5.60%
发文量
122
审稿时长
6 months
期刊介绍: The Journal of Engineering in Medicine is an interdisciplinary journal encompassing all aspects of engineering in medicine. The Journal is a vital tool for maintaining an understanding of the newest techniques and research in medical engineering.
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