Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS-CoV-2 Infection.

IF 9 2区 医学 Q1 VIROLOGY
Soraya Mezouar, Jean-Louis Mege
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引用次数: 0

Abstract

The concept of macrophage polarization has been largely used in human diseases to define a typology of activation of myeloid cells reminiscent of lymphocyte functional subsets. In COVID-19, several studies have investigated myeloid compartment dysregulation and macrophage polarization as an indicator of disease prognosis and monitoring. SARS-CoV-2 induces an in vitro activation state in monocytes and macrophages that does not match the polarization categories in most studies. In COVID-19 patients, monocytes and macrophages are activated but they do not show a polarization profile. Therefore, the investigation of polarization under basic conditions was not relevant to assess monocyte and macrophage activation. The analysis of monocytes and macrophages with high-throughput methods has allowed the identification of new functional subsets in the context of COVID-19. This approach proposes an innovative stratification of myeloid cell activation. These new functional subsets of myeloid cells would be better biomarkers to assess the risk of complications in COVID-19, reserving the concept of polarization for pharmacological programme evaluation. This review reappraises the polarization of monocytes and macrophages in viral infections, particularly in COVID-19.

传染性疾病巨噬细胞极化监测:SARS-CoV-2感染的启示
巨噬细胞极化的概念在人类疾病中被广泛用于定义骨髓细胞激活的类型,使人想起淋巴细胞功能亚群。在COVID-19中,一些研究将骨髓室失调和巨噬细胞极化作为疾病预后和监测的指标。SARS-CoV-2在单核细胞和巨噬细胞中诱导的体外激活状态在大多数研究中与极化类别不匹配。在COVID-19患者中,单核细胞和巨噬细胞被激活,但它们不表现出极化特征。因此,在基本条件下的极化研究与单核细胞和巨噬细胞活化的评估无关。利用高通量方法对单核细胞和巨噬细胞进行分析,可以在COVID-19背景下识别新的功能亚群。这种方法提出了一种髓细胞活化的创新分层。这些新的髓样细胞功能亚群将成为评估COVID-19并发症风险的更好的生物标志物,为药理学方案评估保留极化概念。这篇综述重新评估了单核细胞和巨噬细胞在病毒感染中的极化,特别是在COVID-19中。
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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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