Ammar Saadoon Alishlash, Zhihong Yu, Ahmed Lazrak, Ryne Simpson, Guillermo Beltran Ale, William T Harris, Sadis Matalon
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引用次数: 0
Abstract
Objectives: Low molecular-weight hyaluronic acid (LMW-HA) is produced by the degradation of high-molecular-weight hyaluronic acid at the pulmonary interstitium and alveolar epithelium by reactive intermediates following lung injury. We aimed to investigate the role of bronchoalveolar lavage (BAL) LMW-HA as a biomarker of pediatric chronic pulmonary aspiration (CPA).
Methods: Single-center prospective comparison of LMW-HA presence in BAL in pediatric Aerodigestive patients with and without CPA undergoing clinically indicated bronchoscopy. Pediatric pulmonologists diagnosed CPA based on video-fluoroscopic swallowing evaluation.
Results: Fifteen children (mean age 6.1 years, male predominance at 73%, and 53% with CPA) were enrolled. Children with CPA have comparable baseline characteristics (age, sex, and race), but their BAL had higher white blood cell count, higher neutrophil percentages, higher bacterial culture positivity rates, and lower macrophage percentages than those without CPA. The two groups were comparable in sex, BAL lymphocyte percentages, eosinophil percentages, red blood cell counts, and lipid-laden macrophage positivity. Detection of BAL LMW-HA in the BAL had a 100% specificity and 88% sensitivity for CPA diagnosis. BAL protein levels were higher in the CPA group and in participants with positive LMW-HA.
Conclusions: We suggest BAL LMW-HA as a potential novel biomarker of pediatric CPA with high specificity and sensitivity. BAL LMW-HA is not detectable in subjects without CPA and is associated with increased BAL protein levels.
期刊介绍：
Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases.
PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.
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