Does serum Gas6 level change in active uveitis?

IF 2.3 Q2 OPHTHALMOLOGY
Therapeutic Advances in Ophthalmology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI:10.1177/25158414251328558
Ozgur Cakici, Omer Faruk Yilmaz
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引用次数: 0

Abstract

Purpose: The aim of this study was to investigate serum Growth Arrest-Specific Protein 6 (Gas6) levels in the active and inactive periods of uveitis.

Material and methods: In this study, serum Gas6 levels were evaluated in 21 patients during active and inactive periods. After measuring serum Gas6 levels in the active phase, the serum Gas6 test was repeated in the inactive period. Commercial Enzyme-Linked Immunosorbent Assay (ELISA) kits (Gas6, WKEA Med Supplies Corporation, NY, USA) were used to measure Gas6 levels. Plasma concentrations were analyzed with an ELISA reader at 450 nm following the manufacturer's instructions.

Results: In the study, the mean age of 21 patients was 33 (7-62) years. The mean follow-up period was 30.05 ± 18.76 months. While the average Gas6 value measured during active uveitis attacks was 1.02 ± 0.39 ng/mL (range: 0.54-2.12), the Gas6 value during the passive period was 0.71 ± 0.23 ng/mL (range: 0.39-1.17). The Gas6 level during active uveitis attacks was significantly higher than during the passive period (p = 0.04).

Conclusion: The findings of this study suggest a notable elevation in serum Gas6 levels across all cases of active uveitis, irrespective of the underlying etiology, whether infectious or noninfectious. To successfully integrate serum Gas6 levels into the diagnostic and follow-up protocols for active uveitis, additional comprehensive investigations are imperative.

Abstract Image

Abstract Image

活动性葡萄膜炎患者血清Gas6水平改变吗?
目的:本研究的目的是研究葡萄膜炎活动性和非活动性时期血清生长抑制特异性蛋白6 (Gas6)水平。材料与方法:本研究测定了21例患者在活动期和活动期的血清Gas6水平。在活跃期测定血清Gas6水平后,在非活跃期重复血清Gas6测试。使用商用酶联免疫吸附试验(ELISA)试剂盒(Gas6, WKEA Med Supplies Corporation, NY, USA)检测Gas6水平。按照制造商的说明,用ELISA读取器在450 nm处分析血浆浓度。结果:本组21例患者平均年龄33岁(7 ~ 62岁)。平均随访时间为30.05±18.76个月。活动性葡萄膜炎发作时平均Gas6值为1.02±0.39 ng/mL(范围:0.54 ~ 2.12),被动期平均Gas6值为0.71±0.23 ng/mL(范围:0.39 ~ 1.17)。活性葡萄膜炎发作时Gas6水平明显高于被动发作期(p = 0.04)。结论:本研究结果表明,所有活动性葡萄膜炎患者血清Gas6水平均显著升高,无论其潜在病因是感染性还是非感染性。为了成功地将血清Gas6水平整合到活动性葡萄膜炎的诊断和随访方案中,必须进行额外的全面调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
44
审稿时长
12 weeks
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