Slow-wave sleep is associated with nucleus accumbens volume in elderly adults

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-03-24 DOI:10.1016/j.neuroimage.2025.121173

Kitti Bán , Ádám Nárai , Noémi Báthori , Éva M. Bankó , Adél Bihari , Vivien Tomacsek , Tibor Kovács , Béla Weiss , Petra Hermann , Péter Simor , Zoltán Vidnyánszky

引用次数: 0

Abstract

Slow-wave sleep (SWS) is essential for restorative neural processes and its decline is associated with both healthy and pathological ageing. Building on previous rodent research, this longitudinal study identified a significant association between nucleus accumbens (NAcc) volume and SWS duration in cognitively unimpaired older adults, whilst no significant link was observed between NAcc volume and N2 or rapid eye movement (REM) sleep percentage. Our findings support the involvement of the NAcc in ageing-related modulation of SWS and thus suggest the NAcc as a potential neural marker or therapeutic target for improving SWS.

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慢波睡眠（SWS）对神经恢复过程至关重要，其衰退与健康和病理衰老都有关系。在以前的啮齿动物研究基础上，这项纵向研究发现，在认知能力未受损的老年人中，伏隔核（NAcc）体积与慢波睡眠持续时间之间存在显著关联，而在伏隔核（NAcc）体积与N2或快速眼动（REM）睡眠百分比之间未观察到显著关联。我们的研究结果表明，NAcc参与了与衰老相关的SWS调节，因此建议将NAcc作为改善SWS的潜在神经标记或治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.