One-year outcomes after switching to faricimab in eyes with pre-treated neovascular age-related macular degeneration: a Swiss Retina Research Network report.
Gabriela Grimaldi, Aude Ambresin, Isabel B Pfister, Christin Schild, Christina Plasencia, Katja Hatz, Richard Stillenmunkes, Marion R Munk, Arianna Paris, Moreno Menghini, Dmitri Artemiev, Andreas Ebneter, Jennifer Cattaneo, Eva C de Oliveira Figueiredo, Chiara M Eandi, Jacqueline Fröhlich, Nicolas Feltgen, Tahm Spitznagel, Gábor Márk Somfai, Mariano Cozzi, Sandrine Zweifel, Andreas Weinberger, Justus G Garweg
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引用次数: 0
Abstract
Purpose: To report the efficacy and safety of switching to faricimab in a real-world, Swiss cohort of patients with pre-treated neovascular age-related macular degeneration (nAMD).
Design: Retrospective, multicenter, longitudinal observational study conducted at 11 centers of the Swiss Retina Research Network.
Subjects: We included 353 eyes of 325 patients who were switched to intravitreal faricimab after prior anti-vascular endothelial growth factor (anti-VEGF) therapy and followed for a minimum of 12 months between May 1, 2022 and October 30, 2024.
Methods: Demographic characteristics, baseline functional and optical coherence tomography findings, treatment history, and outcomes at 12 months post-switch to faricimab were extracted from the patients' electronic case report forms.
Main outcome measures: Change in best-corrected visual acuity (BCVA), central subfield thickness (CST), presence of retinal fluid (RF) and pigment epithelial detachment, treatment intervals and safety signals.
Results: Twelve months after switch, mean BCVA remained unchanged while mean CST decreased from 315.3 μm to 263.9 μm (p<0.01). Fast drying (absence of RF) after 1 faricimab injection was observed in 134 eyes (38%) and correlated positively with the treatment interval at 12 months (r(301)=0.24, p<0.01). After 12 months,169 (47.9%) eyes demonstrated absence of retinal fluid compared to 10.2% at switch. Mean treatment interval increased from 5.8 ± 2.5 weeks at switch to 8.3 ± 4.2 weeks at 12 months, whereas extended treatment intervals (≥12-week) were achieved in 20% of patients. Mild intraocular inflammation was reported in 1.7% of cases.
Conclusions: Switching to faricimab in pre-treated nAMD led to sustained anatomical improvements and stabilization of BCVA, with a substantial reduction in RF compared to baseline. Our results suggest the potential benefits of this switch strategy based on real-world data.
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