The current advancements in chitosan nanoparticles in the management of non-surgical periodontitis treatment.

IF 3.6 3区医学 Q3 NANOSCIENCE & NANOTECHNOLOGY

Nanotoxicology Pub Date : 2025-03-28 DOI:10.1080/17435390.2025.2484002

Mehrnaz Sadighi Shamami, Mohammad Ekhlaspour, Jameel M A Sulaiman, Radhwan Abdul Kareem, Nahed Mahmood Ahmed Alsultany, Kamyar Nasiri, Naghmeh Shenasa

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Abstract

Because of the intricate interactions between bacteria internalization in periodontal cells and chronic inflammatory activation, periodontal disorders remain difficult. Furthermore, the primary cause of adult tooth loss is periodontitis, one of the most common dental disorders worldwide. The key to preventing periodontitis has been to reduce the development of bacteria and the generation of substances that eventually erode the tissue surrounding and supporting the teeth. Furthermore, there are several disadvantages to treating periodontitis with antibiotics administered systemically. A naturally occurring polymer with antibacterial and anti-inflammatory properties is chitosan (CS). CS is highly interested in treating periodontal disease as a medicine carrier due to its actions against anaerobic microorganisms and possible anti-inflammatory properties. Due to the multifactorial pathophysiology of periodontitis, combining antimicrobial medications in a single drug delivery method is preferable to administering them separately since it increases the therapeutic range when numerous organisms are present. As a result, CS-based drug delivery technologies, such as gels, micro, and nanoparticles (NPs), were created to transport drugs to the periodontal pocket over an extended period. This research provides an overview of the existing therapeutic benefits of CSNP on periodontitis. This information might be used to create therapeutic substitutes based on CSNP for treating periodontal infections.

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来源期刊

Nanotoxicology 医学-毒理学

CiteScore

10.10

自引率

4.00%

发文量

审稿时长

3.5 months

期刊介绍： Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.