Association between exposure to brominated flame retardants (BFRs) and blood lipid profiles in American adults: a cross-sectional study.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-03-27 DOI:10.1186/s12944-025-02527-4

Yuxuan Wang, Zhihao Zhang, Nana Shen, Xiaoying Qi, Hao Li, Futong Wu, Zhongze Zhu, Jiarui Liu, Hongfei Xiang

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引用次数: 0

Abstract

Background: Exposure to brominated flame retardants (BFRs) has been linked to alterations in human metabolism and disease processes. However, the relationship between BFR exposure and blood lipid levels remains unclear. This study aimed to investigate the potential association between BFR exposure and blood lipid profiles in American adults.

Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. Serum concentrations of twelve BFRs, PBB153 and eleven polybrominated diphenyl ethers (PBDEs), were quantified using isotope dilution gas chromatography/high-resolution mass spectrometry (GC/HRMS). Blood lipid levels, including total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured enzymatically. The Friedewald equation was used to determine low-density lipoprotein cholesterol (LDL-C): [LDL-C] = [TC] - [HDL-C] - [TG/5]. Remnant cholesterol (RC) was calculated using the formula: [RC] = [TC] - [HDL-C] - [LDL-C]. Multivariable regression analyses were applied to examine the associations between individual BFRs and TC, HDL-C, LDL-C, and RC. The overall associations of BFR mixtures with blood lipids were evaluated using quantile g-computation (QGC) analyses and weighted quantile sum (WQS) regression. In order to identify potential gender-specific differences, stratified mixture analyses were performed by gender.

Results: A total of 3,154 eligible participants were included. Nine BFRs with a detection rate greater than 70% were included in the analysis. Individually, PBB153, PBDE209, PBDE153, and PBDE28 were positively associated with TC and RC after adjusted all covariates. Furthermore, PBB153, PBDE209, and PBDE153 were positively associated with LDL-C. No association was found between individual BFR and HDL-C. WQS and QGC analyses confirmed that BFR mixtures were positively associated with TC, LDL-C, and RC.

Conclusion: This study demonstrates that BFR exposure is associated with increased levels of TC, LDL-C, and RC, indicating an elevated risk of dyslipidemia and cardiovascular diseases.

查看原文本刊更多论文

美国成年人接触溴化阻燃剂（BFRs）与血脂之间的关系：一项横断面研究。

背景：暴露于溴化阻燃剂（BFRs）与人体代谢和疾病过程的改变有关。然而，BFR暴露与血脂水平之间的关系尚不清楚。本研究旨在调查美国成年人BFR暴露与血脂谱之间的潜在关联。方法：采用2005-2016年国家健康与营养检查调查（NHANES）数据进行横断面研究。采用同位素稀释气相色谱/高分辨率质谱法（GC/HRMS）测定了12种BFRs、PBB153和11种多溴联苯醚（PBDEs）的血清浓度。用酶法测定血脂水平，包括总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）。采用Friedewald方程测定低密度脂蛋白胆固醇（LDL-C）： [LDL-C] = [TC] - [HDL-C] - [TG/5]。残余胆固醇（RC）计算公式为：[RC] = [TC] - [HDL-C] - [LDL-C]。采用多变量回归分析来检验个体BFRs与TC、HDL-C、LDL-C和RC之间的关系。使用分位数g计算（QGC）分析和加权分位数和（WQS）回归评估BFR混合物与血脂的总体相关性。为了确定潜在的性别差异，按性别进行分层混合分析。结果：共纳入3154名符合条件的受试者。9例检出率大于70%的BFRs纳入分析。调整所有协变量后，PBB153、PBDE209、PBDE153和PBDE28分别与TC和RC呈正相关。此外，PBB153、PBDE209和PBDE153与LDL-C呈正相关。未发现个体BFR与HDL-C之间存在关联。WQS和QGC分析证实BFR混合物与TC、LDL-C和RC呈正相关。结论：本研究表明BFR暴露与TC、LDL-C和RC水平升高相关，表明血脂异常和心血管疾病的风险升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.