Predictive Effect of FT3 Within the Euthyroid Range on HDL-C in Patients With Type 2 Diabetes: A Cross-Sectional Analysis of Inpatients in China

IF 2.6 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2025-03-28 DOI:10.1002/jcla.70029

Jinmei Xu, Shangshuang Zhao, Yan Wang, Jun Han

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Abstract

Background

Evidence for assessing the relationship between free triiodothyronine (FT3) and high-density lipoprotein cholesterol (HDL-C) remains limited. Therefore, the purpose of our study is to evaluate the relationship between FT3 and HDL-C in patients with type 2 diabetes.

Methods

From June 2022 to October 2023, 3011 patients with normal thyroid function and diagnosed with type 2 diabetes mellitus (T2DM) were collected continuously and non-selectively in a Chinese hospital. Then, we used a logistic regression model to explore the relationship between FT3 and HDL-C. Smooth curve fitting is used to identify the nonlinear relationship between FT3 and HDL-C.

Results

After adjusting for the influence of relevant factors, FT3 and HDL-C were negatively correlated −0.02 (−0.04, −0.00; p = 0.0162). There is also a nonlinear relationship between FT3 and HDL-C, with an inflection point of 3.48 pmol/L for FT3 (P for log- likelihood ratio test = 0.044).

Conclusion

This study shows that there is a negative correlation and nonlinear relationship between FT3 and HDL-C in the Chinese population with diabetes. When FT3 is between 2.76–3.48 pmol/L, HDL-C tends to a stable state; When FT3 is between 3.48–6.45 pmol/L, HDL-C decreases with the increase of FT3 concentration (According to the reference range used by our hospital, the normal value of serum FT3 is 2.76–6.45 pmol/L). These findings suggest that maintaining FT3 within the range of 2.76 to 3.48 pmol/L may be most beneficial for mitigating the progression of cardiovascular disease in patients with T2DM.

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甲状腺功能正常范围内FT3对2型糖尿病患者HDL-C的预测作用：中国住院患者的横断面分析

背景：评估游离三碘甲状腺原氨酸（FT3）和高密度脂蛋白胆固醇（HDL-C）之间关系的证据仍然有限。因此，我们研究的目的是评估2型糖尿病患者FT3与HDL-C的关系。方法：于2022年6月至2023年10月，连续非选择性收集国内某医院诊断为2型糖尿病（T2DM）的甲状腺功能正常患者3011例。然后，我们使用逻辑回归模型来探讨FT3与HDL-C之间的关系。采用光滑曲线拟合识别FT3与HDL-C之间的非线性关系。结果：校正相关因素影响后，FT3与HDL-C呈负相关(-0.02,-0.04,-0.00；p = 0.0162)。FT3与HDL-C之间也存在非线性关系，FT3的拐点为3.48 pmol/L（对数似然比检验P = 0.044）。结论：本研究显示中国糖尿病患者FT3与HDL-C呈负相关和非线性关系。当FT3在2.76 ~ 3.48 pmol/L之间时，HDL-C趋于稳定；FT3在3.48 ~ 6.45 pmol/L之间时，HDL-C随FT3浓度的升高而降低（根据我院使用的参考范围，血清FT3正常值为2.76 ~ 6.45 pmol/L）。这些发现表明，将FT3维持在2.76 - 3.48 pmol/L范围内可能对缓解T2DM患者心血管疾病的进展最有利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.