Reducing early pregnancy loss with vitamin D3: an analysis of serum 1,25-(OH)D3 modulation and miscarriage risk.

Abstract

This case-control study of 124 early-pregnant women found that daily supplementation with 400 IU of vitamin D₃ significantly increased serum 1,25-(OH)D₃ levels and was associated with a lower incidence of threatened miscarriage. The study suggests that vitamin D₃ supplementation could reduce the risk of early miscarriage and improve pregnancy outcomes by modulating immune responses and hormonal stability.