Discovery of immunosuppressive secondary metabolites from Hypericum patulum.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-03-27 DOI:10.1080/10286020.2025.2481285

Fei Song, Jie Li, Bin-Bin Song, Zheng-Yi Shi, Zhang-Rong Hou, Ye-Ting Zhang, Yu-Lin Duan, Jian-Ping Wang, Chang-Xing Qi, Yong-Hui Zhang

引用次数: 0

Abstract

The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2-8). Their structures were identified by spectroscopic techniques and single crystal diffraction experiment. Structurally, patutriter A (1) was a new lupane with a 28-nor-skeleton. More importantly, compounds 3-5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and concanavalin A (ConA) stimulated murine splenocytes proliferation, with IC₅₀ values from (15.25 ± 1.78) μM to (22.58 ± 3.47) μM, disclosing that those compounds might serve as potential lead compounds in the development of new immunosuppressants.

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金丝桃免疫抑制次生代谢物的发现。

对金丝桃的化学研究提供了一种新的降解的羽扇烷型三萜，patutriter a(1)和7个已知化合物（2-8）。通过光谱技术和单晶衍射实验对其结构进行了鉴定。在结构上，patutriter A(1)是一个具有28-no -skeleton的新lupane。更重要的是，化合物3-5表现出适度的免疫抑制作用，抑制抗cd3 /抗cd28单克隆抗体（mab）和ConA刺激小鼠脾细胞增殖，IC50值在（15.25±1.78）μM至（22.58±3.47）μM之间，表明这些化合物可能是开发新型免疫抑制剂的潜在先导化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.