The prevalence of mild behavioral impairment in older adults with mild cognitive impairment: A systematic review and meta-analysis.

Abstract

BackgroundMild behavioral impairment is a neurobehavioral symptom characterized by the onset of a new and persistent neuropsychiatric syndrome. Patients with co-occurring mild behavioral impairment and mild cognitive impairment have the relatively highest probability of developing dementia than sick mild behavioral impairment or mild cognitive impairment alone.ObjectiveThis study aimed to determine the currently available best estimate of mild behavioral impairment prevalence and clarify the reasons for the difference in estimates.MethodsData were retrieved and collected from five electronic databases. Two reviewers independently appraised the methodological quality of included studies. Heterogeneity was assessed by using the I² statistic and random effects models were employed. Sources of heterogeneity were investigated by subgroup analysis and meta-regression. All statistical analyses were conducted by Stata.ResultsA total of 23 reports involving 5397 participants were included in this systematic review. The pooled effect size for the overall mild behavioral impairment was 52% (95%CI 42-62%). In the subgroup analysis and regression analysis, we found that study type, study area, assessment tools, and study subject gender could explain part of the source of heterogeneity.ConclusionsThe results of this review suggest that 52% with mild cognitive impairment combined with mild behavioral impairment; there is a close relationship between the two. Future studies should pay more attention to the underlying mechanism between the two and provide a more scientific basis for early discrimination of clinical dementia and Alzheimer's disease.