Assessment of Fetal Cardiac Morphology and Function in Pregnant Women With Systemic Lupus Erythematosus Using Speckle Tracking Echocardiography.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-03-28 DOI:10.1002/jcu.23974

Jian Wu, Yanping Ruan, Hairui Wang, Xiaoyan Gu, Jiancheng Han, Yihua He

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引用次数: 0

Abstract

Purpose: Study aimed to assess fetal heart morphology and function in pregnancies with systemic lupus erythematosus (SLE) utilizing speckle tracking echocardiography (STE) and to evaluate indicators for predicting fetal subclinical cardiac damage in this population.

Methods: The study involved 99 SLE-affected fetuses and 99 gestational age-matched controls. The fetal cardiac morphology and function parameters were calculated using STE (FetalHQ).

Results: The absolute values of left ventricular (LV) global longitudinal strain (GLS), right ventricular (RV) GLS, LV fractional area change (FAC), and RV FAC in the SLE group were lower than those in the control group (p < 0.001). The 24-segment fractional shortening (FS) analysis revealed significantly lower FS in the SLE group than the controls for LV segments 11-12 and RV segments 4-24. The 24-segment sphericity index (SI) analysis indicated significantly lower SI in the SLE group than the controls for LV segments 1-24 and RV segments 1-8. The LV GLS (AUC = 0.859) and RV GLS (AUC = 0.841) could be considered good predictors of subclinical myocardial damage in SLE-affected fetuses.

Conclusions: STE indicated that fetuses in pregnant women with SLE present cardiac morphology and function that have changed compared to the controls. Further investigations are needed to evaluate STE indices such as the GLS, FAC, and 24-segment FS and SI to predict fetal prognosis in pregnant women with SLE.

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.