Skin and beyond: Demographics, clinical features and systemic involvement of cutaneous lupus erythematosus in Pakistani population.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI:10.1177/09612033251330115
Misbah Zakir Abowath, Erum Ashraf, Umair Zakir Abowath
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引用次数: 0

Abstract

BackgroundLupus erythematosus (LE) is an autoimmune disease with skin being the most important organ involved and presents as LE specific and LE nonspecific lesions.ObjectiveTo determine the clinical demographics, systemic involvement and disease impact on daily lives of patients of cutaneous lupus erythematosus (CLE).MethodologyA cross sectional study of a total of 135 patients who presented with cutaneous symptoms were enrolled. Informed consent was taken. Detailed History, examination, clinical features, laboratory and radiograph investigations were conducted to assess the systemic involvement of internal organs.ResultsOf the 135 patients, 73.3% patients were female and 26.7% were male. Mean age was 28.1 years and duration of CLE was 8.4 months. 56.3% of patients belonged to the rural area. Isolated Chronic CLE (CCLE) was observed in 35.5%, CCLE with overlap Acute CLE (ACLE) in 30.3% and Isolated ACLE in 33.3%. Only two patients had Sub acute CLE (SCLE). In LE specific lesions, limited and generalized discoid rash was noted in 33.3% and 17.7% respectively. 46.6% patients had Malar rash. Oral and nasal ulcers were observed in 51.1 %. Non scarring alopecia was seen in 53.3% of patients. Scarring alopecia was observed in 35.5%. 34% patients had Raynaud's phenomenon, 23.7% had Periungual telangiectasia, and 14.8% had Vasculitis. In systemic involvement, joint involvement was observed in 49 patients (36.3%), renal in 48 patients (35.6%), haematological in 42 patients (31.1%), serositis, 23 patients (17%) and neurological in 14 patients (10.4%). No difference in sexes was observed. ANA positivity was seen in 61 patients, (45.1%), most of whom were females. (56.5%) Anti DSDNA was positive in 42 patients (31.1%) of which 40 were women. Mean DLQI was 11.01 ± 8.2. 45 patients had no or slight effect on their lives. 22.9%, 27.4% and 16.3% had moderate, large and very large effects of CLE on their lifestyle.ConclusionThe clinical characteristics of cutaneous lupus is similar to other studies, but the renal involvement is higher with cutaneous involvement in this study, while Serositis is less prevalent. Localized discoid lupus did not show extra cutaneous involvement, but showed significant impact on daily life.

皮肤及其他:巴基斯坦人群中皮肤红斑狼疮的人口统计学、临床特征和系统性累及。
背景红斑狼疮(leus erythematosus, LE)是一种自身免疫性疾病,皮肤是最重要的受累器官,表现为LE特异性和LE非特异性病变。目的了解皮肤红斑狼疮(CLE)患者的临床人口学特征、全身累及及疾病对日常生活的影响。方法对135例出现皮肤症状的患者进行横断面研究。采取知情同意。详细的病史,检查,临床特征,实验室和x线片调查进行评估内脏器官的全身累及。结果135例患者中,女性占73.3%,男性占26.7%。平均年龄28.1岁,CLE持续时间8.4个月。56.3%的患者来自农村地区。孤立性慢性CLE (CCLE)占35.5%,CCLE合并急性CLE (CCLE)占30.3%,孤立性CLE占33.3%。只有2例患者发生亚急性CLE (SCLE)。在LE特异性病变中,局限性和广泛性盘状皮疹分别占33.3%和17.7%。46.6%的患者出现马拉尔疹。口腔和鼻腔溃疡占51.1%。非瘢痕性脱发占53.3%。35.5%为瘢痕性脱发。34%的患者有雷诺现象,23.7%的患者有趾周毛细血管扩张,14.8%的患者有血管炎。在系统受累方面,49例(36.3%)受累于关节,48例(35.6%)受累于肾脏,42例(31.1%)受累于血液病,23例(17%)受累于血清炎,14例(10.4%)受累于神经系统。没有观察到性别差异。ANA阳性61例(45.1%),以女性居多。抗DSDNA阳性42例(31.1%),其中女性40例。DLQI平均值为11.01±8.2。45名患者的生活没有或只有轻微的影响。22.9%、27.4%和16.3%的人对CLE的生活方式有中等、较大和非常大的影响。结论皮肤性狼疮的临床特征与其他研究相似,但本研究中皮肤性狼疮对肾脏的累及较高,而浆液炎的发生率较低。局部性盘状狼疮没有表现出皮肤外受累,但对日常生活有显著影响。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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