Fatty pancreas on EUS: Risk factors, correlation with CT/MRI, and implications for pancreatic cancer screening.

IF 4.4 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Endoscopic Ultrasound Pub Date : 2025-01-01 Epub Date: 2025-03-03 DOI:10.1097/eus.0000000000000109
Ramez M Ibrahim, Shantanu Solanki, Wei Qiao, Hyunsoo Hwang, Ben S Singh, Irina M Cazacu, Adrian Saftoiu, Matthew H G Katz, Michael P Kim, Florencia McAllister, Manoop S Bhutani
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引用次数: 0

Abstract

Background and objectives: Fatty pancreas (FP), traditionally perceived as a benign finding, has been undergoing scrutiny lately due to growing evidence linking it to various disease states, including increased risk for pancreatic cancer (PC).

Methods: A retrospective study of patients who underwent EUS at a single institution from August 2007 to October 2023, conducted by one endosonographer with more than 25 years of experience. Focusing on individuals identified with FP during EUS, we compared these findings with corresponding findings on computed tomography/magnetic resonance imaging (CT/MRI) conducted within 3 months or 1 year prior to or following EUS.

Results: Ninety-one patients were included and identified as having FP on their EUS exams. The most common indication for EUS was PC screening in high-risk patients (35.16%). At the time of conducting EUS, 65.93% of patients had a body mass index (BMI) ≥30, 63.73% had hypertension, and 32.96% had type 2 diabetes mellitus (DM). Of the 91 patients, 70 had CT or MRI done within 3 months of the EUS date, and only 15 (21.43%) had FP reported on imaging. All 91 patients had CT or MRI within 1 year, and only 16 (17.58%) had FP reported on imaging.

Conclusion: Only 21.43% of patients had FP on their CT/MRI within 3 months despite EUS findings, suggesting either lower accuracy of CT/MRI compared to EUS in identifying FP or potential underreporting in a real-world setting, even in a tertiary care center. This discrepancy in reporting is noteworthy considering FP's role as a potential precursor to several important conditions and promoting pancreatic carcinogenesis pathways.

EUS的脂肪胰腺:危险因素,与CT/MRI的相关性,以及胰腺癌筛查的意义。
背景和目的:脂肪性胰腺(FP),传统上被认为是一种良性发现,最近由于越来越多的证据将其与各种疾病状态联系起来,包括胰腺癌(PC)的风险增加,因此一直受到密切关注。方法:回顾性研究2007年8月至2023年10月在单一机构接受EUS的患者,由一名具有25年以上经验的超声医师进行。针对在EUS期间确诊为FP的个体,我们将这些发现与EUS前后3个月或1年内进行的计算机断层扫描/磁共振成像(CT/MRI)的相应发现进行了比较。结果:纳入91例患者,并在EUS检查中确定为FP。高危患者中最常见的适应症是PC筛查(35.16%)。进行EUS检查时,65.93%的患者体重指数(BMI)≥30,63.73%的患者患有高血压,32.96%的患者患有2型糖尿病。在91例患者中,70例在EUS检查后3个月内进行了CT或MRI检查,仅有15例(21.43%)在影像学上报告了FP。91例患者1年内均行CT或MRI检查,影像学报告FP仅16例(17.58%)。结论:尽管EUS发现FP,但只有21.43%的患者在3个月内在CT/MRI上发现FP,这表明CT/MRI在识别FP方面的准确性低于EUS,或者在现实环境中可能漏报FP,即使在三级医疗中心也是如此。考虑到FP作为几种重要疾病和促进胰腺癌发生途径的潜在前体的作用,这种报道的差异值得注意。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Endoscopic Ultrasound
Endoscopic Ultrasound GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
6.20
自引率
11.10%
发文量
144
期刊介绍: Endoscopic Ultrasound, a publication of Euro-EUS Scientific Committee, Asia-Pacific EUS Task Force and Latin American Chapter of EUS, is a peer-reviewed online journal with Quarterly print on demand compilation of issues published. The journal’s full text is available online at http://www.eusjournal.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal does not charge for submission, processing or publication of manuscripts and even for color reproduction of photographs.
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