Cladosporium species novum Invasive Pulmonary Infection in a Patient with Post-COVID-19 Syndrome and AIDS.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Milorad Bijelović, Nikola Gardić, Aleksandra Lovrenski, Danijela Petrović, Gordana Kozoderović, Vesna Lalošević, Vuk Vračar, Dušan Lalošević
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引用次数: 0

Abstract

Background and Clinical Significance: Since the prevalence of fungal lung infections is increasing, certain agents, such as Cladosporium spp., have emerged as unexpected causes. Cladosporium spp. fungi are ubiquitous in environments such as soil, fruits, and wine corks; they are a part of the normal human skin flora; and they are known respiratory allergens. Case Presentation: A patient with a history of post-COVID-19 syndrome and AIDS presented with lung pathology indicative of an invasive fungal infection. The initial histopathological examination revealed numerous yeast-like cells with narrow-based budding, which led to a mistaken diagnosis of cryptococcosis. However, further detailed examination revealed sparse hyphae in the lung tissue, suggesting a more complex fungal infection. Molecular analyses and sequence BLAST alignment were performed, ultimately identifying the infectious agent as "Cladosporium species novum", a rare cause of invasive pulmonary cladosporiasis. Conclusions: Invasive pulmonary cladosporiasis is a rare condition, and the morphological features of the fungus alone were insufficient to establish a correct diagnosis. A comprehensive pathohistological and molecular approach with bioinformatics tools is essential for the correct identification of rare and potentially life-threatening fungal pathogens in immunocompromised patients.

新冠肺炎合并艾滋病患者浸润性肺部感染1例。
背景和临床意义:由于肺部真菌感染的患病率正在增加,某些药物,如枝孢杆菌,已经作为意想不到的原因出现。枝孢菌在土壤、水果和葡萄酒软木塞等环境中无处不在;它们是正常人类皮肤菌群的一部分;它们是已知的呼吸道过敏原。病例介绍:一名有covid -19后综合征和艾滋病病史的患者,肺部病理提示侵袭性真菌感染。最初的组织病理学检查显示有许多酵母样细胞和狭窄的芽殖,这导致了隐球菌病的误诊。然而,进一步的详细检查显示肺组织中菌丝稀疏,提示更复杂的真菌感染。通过分子分析和序列BLAST分析,最终确定感染因子为“枝孢子菌属novum”,这是一种罕见的侵袭性肺枝孢子虫病。结论:侵袭性肺枝孢子虫病是一种罕见的疾病,仅凭真菌的形态学特征不足以建立正确的诊断。综合病理组织学和分子方法与生物信息学工具是必不可少的正确鉴定罕见和潜在威胁生命的真菌病原体免疫功能低下的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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