Predictive factors for the diagnosis of autoimmune pancreatitis using endoscopic ultrasound-guided tissue acquisition: a retrospective study in Japan.

IF 2.3 Q3 GASTROENTEROLOGY & HEPATOLOGY

Clinical Endoscopy Pub Date : 2025-05-01 Epub Date: 2025-03-28 DOI:10.5946/ce.2024.238

Keisuke Yonamine, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Hiroaki Kusunose, Toshitaka Sakai, Kazuaki Miyamoto, Fumisato Kozakai, Haruka Okano, Yuto Matsuoka, Kento Hosokawa, Hidehito Sumiya, Yutaka Noda, Kei Ito

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Abstract

Background/aims: The factors affecting the detection rate of lymphoplasmacytic sclerosing pancreatitis (LPSP) using endoscopic ultrasound-guided tissue acquisition (EUS-TA) in patients with type 1 autoimmune pancreatitis (AIP) have not been thoroughly studied. Therefore, we conducted a retrospective study to identify the predictive factors for histologically detecting level 1 or 2 LPSP using EUS-TA.

Methods: Fifty patients with AIP were included in this study, and the primary outcome measures were the predictive factors for histologically detecting level 1 or 2 LPSP using EUS-TA.

Results: Multivariate analysis identified the use of fine needle biopsy (FNB) needles as a significant predictive factor for LPSP detection (odds ratio, 15.1; 95% confidence interval, 1.62-141; ¬¬p=0.017). The rate of good-quality specimens (specimen adequacy score ≥4) was significantly higher for the FNB needle group than for the fine needle aspiration (FNA) needle group (97% vs. 56%; p<0.01), and the FNB needle group required significantly fewer needle passes than the FNA needle group (median, 2 vs. 3; p<0.01).

Conclusions: The use of FNB needles was the most important factor for the histological confirmation of LPSP using EUS-TA in patients with type 1 AIP.

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超声内镜引导下组织采集诊断自身免疫性胰腺炎的预测因素：日本的一项回顾性研究

背景/目的：内镜超声引导下组织采集（EUS-TA）对1型自身免疫性胰腺炎（AIP）患者淋巴浆细胞性硬化性胰腺炎（LPSP）检出率的影响因素研究尚不深入。因此，我们进行了一项回顾性研究，以确定使用EUS-TA在组织学上检测1级或2级LPSP的预测因素。方法：本研究纳入50例AIP患者，主要结局指标为EUS-TA组织学检测1级或2级LPSP的预测因素。结果：多因素分析发现，细针活检（FNB）针的使用是LPSP检测的重要预测因素(优势比，15.1；95%置信区间为1.62-141；¬¬p = 0.017)。FNB针组标本质量优良率（标本充分性评分≥4）显著高于细针抽吸（FNA）针组(97% vs. 56%；结论：FNB针的使用是EUS-TA对1型AIP患者LPSP组织学证实的最重要因素。

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