Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis.

IF 8.4 2区 医学 Q1 ALLERGY
Zhaoran Wang, Yi Jiao, Wenya Diao, Tong Shi, Qishun Geng, Chaoying Wen, Jiahe Xu, Tiantian Deng, Xiaoya Li, Lu Zhao, Jienan Gu, Tingting Deng, Cheng Xiao
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Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease involving activation of the immune system and the infiltration of immune cells. As the first immune cells to reach the site of inflammation, neutrophils perform their biological functions by releasing many active substances and forming neutrophil extracellular traps (NETs). The overactivated neutrophils in patients with RA not only directly damage tissues but also, more importantly, interact with various other immune cells and broadly activate innate and adaptive immunity, leading to irreversible joint damage. However, owing to the pivotal role and complex influence of neutrophils in maintaining homoeostasis, the treatment of RA by targeting neutrophils is very difficult. Therefore, a comprehensive understanding of the interaction pathways between neutrophils and various other immune cells is crucial for the development of neutrophils as a new therapeutic target for RA. In this study, the important role of neutrophils in the pathogenesis of RA through their crosstalk with various other immune cells and nonimmune cells is highlighted. The potential of epigenetic modification of neutrophils for exploring the pathogenesis of RA and developing therapeutic approaches is also discussed. In addition, several models for studying cell‒cell interactions are summarized to support further studies of neutrophils in the context of RA.

类风湿性关节炎(RA)是一种全身性自身免疫性疾病,涉及免疫系统的激活和免疫细胞的浸润。作为最先到达炎症部位的免疫细胞,中性粒细胞通过释放多种活性物质和形成中性粒细胞胞外捕获物(NET)来发挥其生物功能。RA 患者体内过度激活的中性粒细胞不仅会直接损伤组织,更重要的是,它们还会与其他各种免疫细胞相互作用,广泛激活先天性免疫和适应性免疫,从而导致不可逆转的关节损伤。然而,由于中性粒细胞在维持体内平衡中的关键作用和复杂影响,通过靶向中性粒细胞治疗 RA 非常困难。因此,全面了解中性粒细胞与其他各种免疫细胞之间的相互作用途径对于将中性粒细胞发展为治疗RA的新靶点至关重要。本研究强调了中性粒细胞通过与其他各种免疫细胞和非免疫细胞的相互作用在RA发病机制中的重要作用。还讨论了中性粒细胞表观遗传修饰在探索 RA 发病机制和开发治疗方法方面的潜力。此外,还总结了几种研究细胞-细胞相互作用的模型,以支持在RA背景下对中性粒细胞的进一步研究。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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