Associations of Head and Neck Cancer with Prior Allergic Rhinitis.

IF 4.5 2区 医学 Q1 ONCOLOGY
Cancers Pub Date : 2025-03-17 DOI:10.3390/cancers17061000
Shih-Han Hung, Tzong-Hann Yang, Herng-Ching Lin, Chin-Shyan Chen
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引用次数: 0

Abstract

Background/Objectives: Chronic inflammation has been implicated in cancer development, but the association between allergic rhinitis (AR) and head and neck cancer (HNC) remains unclear. This study aims to investigate this potential relationship using a population-based dataset. Methods: Utilizing the Taiwan Longitudinal Health Insurance Database 2010, we conducted a case-control study encompassing 14,913 HNC patients and 59,652 propensity-score matched controls. Multivariate logistic regression analyses were performed to quantitatively evaluate the association between HNC and prior AR, adjusting for demographic factors and medical comorbidities such as hyperlipidemia, diabetes, hypertension, tobacco use disorder, HPV infection, and alcohol-related disorders. Results: This study identified that 20.19% of the entire cohort had a prior diagnosis of AR, with a significantly higher prevalence in HNC patients relative to controls (26.2% vs. 18.70%). The adjusted odds ratio (OR) for previous AR in HNC patients was 1.559 (95% CI = 1.494-1.627). Furthermore, site-specific analysis revealed increased odds ratios for AR among patients with cancers of the larynx (OR = 1.537, 95% CI = 1.307-1.807), hypopharynx (OR = 1.220, 95% CI = 1.035-1.437), nasopharynx (OR = 2.933, 95% CI = 2.722-3.160), sinonasal (OR = 3.100, 95% CI = 2.424-3.964), salivary glands (OR = 1.470, 95% CI = 1.158-1.865), and thyroid (OR = 1.566, 95% CI = 1.447-1.693). Conclusions: The findings robustly support a significant link between AR and an elevated risk of developing HNC, notably affecting the nasopharynx, sinonasal cavities, larynx, salivary glands, and thyroid.

头颈癌与既往变应性鼻炎的关系
背景/目的:慢性炎症与癌症发展有关,但变应性鼻炎(AR)与头颈癌(HNC)之间的关系尚不清楚。本研究旨在使用基于人口的数据集来调查这种潜在的关系。方法:利用台湾健康保险纵向数据库2010,我们进行了一项病例对照研究,包括14,913名HNC患者和59,652名倾向评分匹配的对照组。进行多变量logistic回归分析,定量评估HNC与既往AR之间的关系,调整人口统计学因素和医学合并症,如高脂血症、糖尿病、高血压、烟草使用障碍、HPV感染和酒精相关疾病。结果:本研究发现,整个队列中有20.19%的人先前诊断为AR, HNC患者的患病率明显高于对照组(26.2%对18.70%)。HNC患者既往AR的校正优势比(OR)为1.559 (95% CI = 1.494-1.627)。此外,位点特异性分析显示,喉癌(OR = 1.537, 95% CI = 1.305 -1.807)、下咽癌(OR = 1.220, 95% CI = 1.035-1.437)、鼻咽癌(OR = 2.933, 95% CI = 2.722-3.160)、鼻窦癌(OR = 3.100, 95% CI = 2.424-3.964)、唾液腺癌(OR = 1.470, 95% CI = 1.155 -1.865)和甲状腺癌(OR = 1.566, 95% CI = 1.447-1.693)患者发生AR的比值比增加。结论:研究结果有力地支持AR与HNC发生风险升高之间的显著联系,特别是影响鼻咽部、鼻腔、喉部、唾液腺和甲状腺。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cancers
Cancers Medicine-Oncology
CiteScore
8.00
自引率
9.60%
发文量
5371
审稿时长
18.07 days
期刊介绍: Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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