Liver Extracellular Matrix in Colorectal Liver Metastasis.

IF 4.5 2区医学 Q1 ONCOLOGY

Cancers Pub Date : 2025-03-12 DOI:10.3390/cancers17060953

Marika Morabito, Pauline Thibodot, Anthony Gigandet, Philippe Compagnon, Christian Toso, Ekaterine Berishvili, Stéphanie Lacotte, Andrea Peloso

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引用次数: 0

Abstract

The liver is the most common site of metastasis of colorectal cancer (CRC), and colorectal liver metastasis is one of the major causes of CRC-related deaths worldwide. The tumor microenvironment, particularly the extracellular matrix (ECM), plays a critical role in CRC metastasis and chemoresistance. Based on findings from clinical and basic research, this review attempts to offer a complete understanding of the role of the ECM in colorectal liver metastasis and to suggest potential ways for therapeutic intervention. First, the ECMs' role in regulating cancer cell fate is explored. We then discuss the hepatic ECM fingerprint and its influence on the metastatic behavior of CRC cells, highlighting key molecular interactions that promote metastasis. In addition, we examine how changes in the ECM within the metastatic niche contribute to chemoresistance, focusing on ECM remodeling by ECM stiffening and the activation of specific signaling pathways. Understanding these mechanisms is crucial for the development of novel strategies to overcome metastasis and improve outcomes for CRC patients.

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结直肠癌肝转移中的肝细胞外基质

肝脏是结直肠癌（CRC）最常见的转移部位，结直肠癌肝转移是全球结直肠癌相关死亡的主要原因之一。肿瘤微环境，特别是细胞外基质（ECM）在结直肠癌转移和化疗耐药中起着关键作用。基于临床和基础研究的发现，本文试图全面了解ECM在结直肠癌肝转移中的作用，并提出治疗干预的潜在方法。首先，探讨了ecm在调节癌细胞命运中的作用。然后，我们讨论了肝ECM指纹及其对CRC细胞转移行为的影响，强调了促进转移的关键分子相互作用。此外，我们研究了转移性生态位内ECM的变化如何促进化学耐药，重点关注通过ECM硬化和特定信号通路的激活来重塑ECM。了解这些机制对于开发克服转移和改善结直肠癌患者预后的新策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancers Medicine-Oncology

CiteScore

8.00

自引率

9.60%

发文量

5371

审稿时长

18.07 days

期刊介绍： Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.