Anthony-Joe Nassour, Anika Jain, Hadia Khanani, Nicholas Hui, Nadine J Thompson, Brian Sorensen, Sris Baskaranathan, Philip Bergersen, Venu Chalasani, Thomas Dean, Max Dias, Michael Wines, James Symons, Lisa Tarlinton, Henry Woo
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引用次数: 0
Abstract
Background: The maximum standardised uptake value (SUVmax) can potentially be affected by the uptake period during PSMA PET imaging. The optimal image acquisition period for 2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL)PSMA PET/CT is yet to be established. This study aims to evaluate the effect of the uptake period on the SUVmax in diagnosing localised, clinically significant prostate cancer using 18F-DCFPyL-PSMA PET/CT.
Methods: Sixty biopsy-naive men with one or more PI-RADS 4 or 5 lesions of at least 10 mm on multiparametric MRI (mpMRI) were enrolled to undergo 18F-DCFPyL-PSMA PET/CT. SUVmax was prospectively measured following an uptake period of 60, 90 and 120 min post injection of 18F-DCFPyL-PSMA radiotracer. Concordance with biopsy results or final histopathology was recorded.
Results: Mean absolute differences in SUVmax at 60 vs. 90, 60 vs. 120, and 90 vs. 120 min uptake periods were 3.23 (SD 4.76), 4.53 (SD 7.33), and 3.24 (SD 4.56), respectively. This represents a statistically significant systematic increase in SUVmax (p-value < 0.001) with increasing uptake period. The interval between the uptake period of 60 vs. 120 min represented the largest SUVmax change of 29.98%.
Conclusions: The SUVmax is a dynamic variable significantly affected by uptake period. Our study supports image acquisition at 120 min following injection of 18F-DCFPyL radiotracer. Further studies are needed to determine if this acquisition period can be applied to other Fluorine-18 based PSMA radiotracers.
期刊介绍:
Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.