Anthony-Joe Nassour, Anika Jain, Hadia Khanani, Nicholas Hui, Nadine J Thompson, Brian Sorensen, Sris Baskaranathan, Philip Bergersen, Venu Chalasani, Thomas Dean, Max Dias, Michael Wines, James Symons, Lisa Tarlinton, Henry Woo
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引用次数: 0
Abstract
Background: The maximum standardised uptake value (SUVmax) can potentially be affected by the uptake period during PSMA PET imaging. The optimal image acquisition period for 2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL)PSMA PET/CT is yet to be established. This study aims to evaluate the effect of the uptake period on the SUVmax in diagnosing localised, clinically significant prostate cancer using 18F-DCFPyL-PSMA PET/CT.
Methods: Sixty biopsy-naive men with one or more PI-RADS 4 or 5 lesions of at least 10 mm on multiparametric MRI (mpMRI) were enrolled to undergo 18F-DCFPyL-PSMA PET/CT. SUVmax was prospectively measured following an uptake period of 60, 90 and 120 min post injection of 18F-DCFPyL-PSMA radiotracer. Concordance with biopsy results or final histopathology was recorded.
Results: Mean absolute differences in SUVmax at 60 vs. 90, 60 vs. 120, and 90 vs. 120 min uptake periods were 3.23 (SD 4.76), 4.53 (SD 7.33), and 3.24 (SD 4.56), respectively. This represents a statistically significant systematic increase in SUVmax (p-value < 0.001) with increasing uptake period. The interval between the uptake period of 60 vs. 120 min represented the largest SUVmax change of 29.98%.
Conclusions: The SUVmax is a dynamic variable significantly affected by uptake period. Our study supports image acquisition at 120 min following injection of 18F-DCFPyL radiotracer. Further studies are needed to determine if this acquisition period can be applied to other Fluorine-18 based PSMA radiotracers.
背景:最大标准化摄取值(SUVmax)可能会受到PSMA PET成像期间摄取期的影响。2-(3-{1-羧基-5-[(6- 18f -氟吡啶-3-羰基)-氨基]-戊基}-脲基)-戊二酸(18F-DCFPyL)PSMA PET/CT的最佳图像采集周期尚未确定。本研究旨在评估摄取周期对SUVmax在18F-DCFPyL-PSMA PET/CT诊断局限性临床显著前列腺癌中的作用。方法:60名未接受活检的男性,在多参数MRI (mpMRI)上有一个或多个PI-RADS 4或5个至少10毫米的病变,接受18F-DCFPyL-PSMA PET/CT检查。在注射18F-DCFPyL-PSMA放射性示踪剂后60、90和120分钟的摄取期,前瞻性地测量SUVmax。记录与活检结果或最终组织病理学的一致性。结果:60 min vs. 90 min、60 min vs. 120 min、90 min vs. 120 min摄取时SUVmax的平均绝对差异分别为3.23 (SD 4.76)、4.53 (SD 7.33)和3.24 (SD 4.56)。这表明随着摄取时间的增加,SUVmax有统计学意义的系统性增加(p值< 0.001)。60 min和120 min摄取期的SUVmax变化最大,为29.98%。结论:SUVmax是一个受摄取期影响较大的动态变量。我们的研究支持在注射18F-DCFPyL放射性示踪剂后120分钟的图像采集。需要进一步的研究来确定这一获取期是否可以应用于其他基于氟-18的PSMA放射性示踪剂。
期刊介绍:
Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.