Impact of Uptake Period on 18F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value.

IF 4.5 2区 医学 Q1 ONCOLOGY
Cancers Pub Date : 2025-03-12 DOI:10.3390/cancers17060960
Anthony-Joe Nassour, Anika Jain, Hadia Khanani, Nicholas Hui, Nadine J Thompson, Brian Sorensen, Sris Baskaranathan, Philip Bergersen, Venu Chalasani, Thomas Dean, Max Dias, Michael Wines, James Symons, Lisa Tarlinton, Henry Woo
{"title":"Impact of Uptake Period on <sup>18</sup>F-DCFPyL-PSMA PET/CT Maximum Standardised Uptake Value.","authors":"Anthony-Joe Nassour, Anika Jain, Hadia Khanani, Nicholas Hui, Nadine J Thompson, Brian Sorensen, Sris Baskaranathan, Philip Bergersen, Venu Chalasani, Thomas Dean, Max Dias, Michael Wines, James Symons, Lisa Tarlinton, Henry Woo","doi":"10.3390/cancers17060960","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The maximum standardised uptake value (SUV<sub>max</sub>) can potentially be affected by the uptake period during PSMA PET imaging. The optimal image acquisition period for 2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (<sup>18</sup>F-DCFPyL)PSMA PET/CT is yet to be established. This study aims to evaluate the effect of the uptake period on the SUV<sub>max</sub> in diagnosing localised, clinically significant prostate cancer using <sup>18</sup>F-DCFPyL-PSMA PET/CT.</p><p><strong>Methods: </strong>Sixty biopsy-naive men with one or more PI-RADS 4 or 5 lesions of at least 10 mm on multiparametric MRI (mpMRI) were enrolled to undergo <sup>18</sup>F-DCFPyL-PSMA PET/CT. SUV<sub>max</sub> was prospectively measured following an uptake period of 60, 90 and 120 min post injection of <sup>18</sup>F-DCFPyL-PSMA radiotracer. Concordance with biopsy results or final histopathology was recorded.</p><p><strong>Results: </strong>Mean absolute differences in SUV<sub>max</sub> at 60 vs. 90, 60 vs. 120, and 90 vs. 120 min uptake periods were 3.23 (SD 4.76), 4.53 (SD 7.33), and 3.24 (SD 4.56), respectively. This represents a statistically significant systematic increase in SUV<sub>max</sub> (<i>p</i>-value < 0.001) with increasing uptake period. The interval between the uptake period of 60 vs. 120 min represented the largest SUV<sub>max</sub> change of 29.98%.</p><p><strong>Conclusions: </strong>The SUV<sub>max</sub> is a dynamic variable significantly affected by uptake period. Our study supports image acquisition at 120 min following injection of <sup>18</sup>F-DCFPyL radiotracer. Further studies are needed to determine if this acquisition period can be applied to other Fluorine-18 based PSMA radiotracers.</p>","PeriodicalId":9681,"journal":{"name":"Cancers","volume":"17 6","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11940267/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancers","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/cancers17060960","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: The maximum standardised uptake value (SUVmax) can potentially be affected by the uptake period during PSMA PET imaging. The optimal image acquisition period for 2-(3-{1-carboxy-5-[(6-18F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (18F-DCFPyL)PSMA PET/CT is yet to be established. This study aims to evaluate the effect of the uptake period on the SUVmax in diagnosing localised, clinically significant prostate cancer using 18F-DCFPyL-PSMA PET/CT.

Methods: Sixty biopsy-naive men with one or more PI-RADS 4 or 5 lesions of at least 10 mm on multiparametric MRI (mpMRI) were enrolled to undergo 18F-DCFPyL-PSMA PET/CT. SUVmax was prospectively measured following an uptake period of 60, 90 and 120 min post injection of 18F-DCFPyL-PSMA radiotracer. Concordance with biopsy results or final histopathology was recorded.

Results: Mean absolute differences in SUVmax at 60 vs. 90, 60 vs. 120, and 90 vs. 120 min uptake periods were 3.23 (SD 4.76), 4.53 (SD 7.33), and 3.24 (SD 4.56), respectively. This represents a statistically significant systematic increase in SUVmax (p-value < 0.001) with increasing uptake period. The interval between the uptake period of 60 vs. 120 min represented the largest SUVmax change of 29.98%.

Conclusions: The SUVmax is a dynamic variable significantly affected by uptake period. Our study supports image acquisition at 120 min following injection of 18F-DCFPyL radiotracer. Further studies are needed to determine if this acquisition period can be applied to other Fluorine-18 based PSMA radiotracers.

摄取时间对18F-DCFPyL-PSMA PET/CT最大标准化摄取值的影响。
背景:最大标准化摄取值(SUVmax)可能会受到PSMA PET成像期间摄取期的影响。2-(3-{1-羧基-5-[(6- 18f -氟吡啶-3-羰基)-氨基]-戊基}-脲基)-戊二酸(18F-DCFPyL)PSMA PET/CT的最佳图像采集周期尚未确定。本研究旨在评估摄取周期对SUVmax在18F-DCFPyL-PSMA PET/CT诊断局限性临床显著前列腺癌中的作用。方法:60名未接受活检的男性,在多参数MRI (mpMRI)上有一个或多个PI-RADS 4或5个至少10毫米的病变,接受18F-DCFPyL-PSMA PET/CT检查。在注射18F-DCFPyL-PSMA放射性示踪剂后60、90和120分钟的摄取期,前瞻性地测量SUVmax。记录与活检结果或最终组织病理学的一致性。结果:60 min vs. 90 min、60 min vs. 120 min、90 min vs. 120 min摄取时SUVmax的平均绝对差异分别为3.23 (SD 4.76)、4.53 (SD 7.33)和3.24 (SD 4.56)。这表明随着摄取时间的增加,SUVmax有统计学意义的系统性增加(p值< 0.001)。60 min和120 min摄取期的SUVmax变化最大,为29.98%。结论:SUVmax是一个受摄取期影响较大的动态变量。我们的研究支持在注射18F-DCFPyL放射性示踪剂后120分钟的图像采集。需要进一步的研究来确定这一获取期是否可以应用于其他基于氟-18的PSMA放射性示踪剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Cancers
Cancers Medicine-Oncology
CiteScore
8.00
自引率
9.60%
发文量
5371
审稿时长
18.07 days
期刊介绍: Cancers (ISSN 2072-6694) is an international, peer-reviewed open access journal on oncology. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信