Genetic influences on macrophage function and lipid uptake in atherosclerosis.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in lipidology Pub Date : 2025-08-01 Epub Date: 2025-03-28 DOI:10.1097/MOL.0000000000000986

Chris A O'Callaghan, Jiahao Jiang

{"title":"Genetic influences on macrophage function and lipid uptake in atherosclerosis.","authors":"Chris A O'Callaghan, Jiahao Jiang","doi":"10.1097/MOL.0000000000000986","DOIUrl":null,"url":null,"abstract":"Purpose of review: Macrophages can accumulate lipid droplets in their cytoplasm resulting in the foamy appearance seen in various diseases, especially atherosclerosis. This review assesses new insights from single cell analyses into the role of different human macrophage subpopulations and genetic risk in atherosclerotic disease.Recent findings: Single cell transcriptomic studies have identified TREM2hi foamy macrophages as a key population in both human and mouse atherosclerotic plaques. In addition, a TREM1hi/PLIN2hi population in human plaques has pro-inflammatory properties. Combined single cell transcriptomic and epigenetic multiomic profiling identified a population of CD52hi lipid-handling macrophages that are enriched for heritability of atherosclerotic disease. Molecular mechanisms have been identified linking gene-regulatory effects of disease-associated polymorphisms to the macrophage response to ox-LDL.Summary: Recent studies have used singe cell approaches to provide new insights into macrophage subsets, their interactions with lipid species and their role in mediating genetic influences on disease risk.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"185-190"},"PeriodicalIF":3.8000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in lipidology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOL.0000000000000986","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: Macrophages can accumulate lipid droplets in their cytoplasm resulting in the foamy appearance seen in various diseases, especially atherosclerosis. This review assesses new insights from single cell analyses into the role of different human macrophage subpopulations and genetic risk in atherosclerotic disease.

Recent findings: Single cell transcriptomic studies have identified TREM2hi foamy macrophages as a key population in both human and mouse atherosclerotic plaques. In addition, a TREM1hi/PLIN2hi population in human plaques has pro-inflammatory properties. Combined single cell transcriptomic and epigenetic multiomic profiling identified a population of CD52hi lipid-handling macrophages that are enriched for heritability of atherosclerotic disease. Molecular mechanisms have been identified linking gene-regulatory effects of disease-associated polymorphisms to the macrophage response to ox-LDL.

Summary: Recent studies have used singe cell approaches to provide new insights into macrophage subsets, their interactions with lipid species and their role in mediating genetic influences on disease risk.

查看原文本刊更多论文

基因对动脉粥样硬化中巨噬细胞功能和脂质摄取的影响。

综述目的：巨噬细胞可以在其细胞质中积聚脂滴，导致泡沫状外观，见于各种疾病，特别是动脉粥样硬化。本综述评估了单细胞分析对不同人类巨噬细胞亚群和遗传风险在动脉粥样硬化疾病中的作用的新见解。最近发现：单细胞转录组学研究已经确定TREM2hi泡沫巨噬细胞是人和小鼠动脉粥样硬化斑块的关键群体。此外，人类斑块中的TREM1hi/PLIN2hi群体具有促炎特性。单细胞转录组学和表观遗传多组学联合分析鉴定了一群CD52hi脂质处理巨噬细胞，它们具有丰富的动脉粥样硬化疾病遗传性。疾病相关多态性的基因调控作用与巨噬细胞对ox-LDL的反应之间的分子机制已经被确定。摘要：最近的研究使用单细胞方法为巨噬细胞亚群、它们与脂质物种的相互作用以及它们在介导疾病风险遗传影响中的作用提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.