Smoking impairs cognitive function through the mediating effect of periodontitis in older adults.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-03-27 DOI:10.1186/s12888-025-06699-2

Xiaoqian Luan, Zhou Jin, Shenhang Xia, Jin Li, Yao An, Jiaqi Gao, Shengya Wang, Huwei Xia, Sipei Pan, Yao Zhang, Weihong Song, Yili Wu

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引用次数: 0

Abstract

Objectives: Evidence has shown that both smoking and periodontitis were linked to cognitive impairment. This study examines whether periodontitis mediates the effects of smoking status on cognitive function in older adults.

Methods: Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, the study included 1728 older participants who have data on smoking, serum cotinine, periodontal examination, and cognitive function. Mediation analysis was performed to test whether extent of periodontitis mediated associations between smoking status and cognitive function, adjusted for sociodemographic and basic health factors.

Results: Compared to never-smokers, daily smokers exhibited significantly worse global cognitive function, with periodontitis mediating this effect (effect= -0.16; 95% CI= -0.29, -0.05). Similarly, periodontitis mediated the association between serum cotinine levels and cognitive function in the total sample (effect= -0.02; 95% CI= -0.03, -0.00).

Conclusions: Periodontitis significantly mediates the impact of smoking on cognitive function. The findings highlight the potential roles of maintaining oral health and smoking cessation in mitigating cognitive decline.

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吸烟通过对老年人牙周炎的中介作用损害认知功能。

目的：有证据表明，吸烟和牙周炎都与认知障碍有关。本研究探讨牙周炎是否介导吸烟状况对老年人认知功能的影响。方法：使用2011-2014年国家健康与营养调查（NHANES）的数据，研究纳入了1728名老年参与者，他们有吸烟、血清可替宁、牙周检查和认知功能的数据。进行中介分析，以检验牙周炎的程度是否介导吸烟状况与认知功能之间的关联，并根据社会人口统计学和基本健康因素进行调整。结果：与不吸烟者相比，每日吸烟者的整体认知功能明显较差，牙周炎介导了这种影响(效应= -0.16；95% ci = -0.29, -0.05)。同样，牙周炎介导了总样本中血清可替宁水平与认知功能之间的关联(效应= -0.02；95% ci = -0.03, -0.00)。结论：牙周炎显著介导吸烟对认知功能的影响。研究结果强调了保持口腔健康和戒烟在减轻认知能力下降方面的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.