Correlation between peripheral lymphocyte subsets monitoring and COVID-19 pneumonia in kidney transplant recipients.

IF 3.4 3区 医学 Q2 INFECTIOUS DISEASES
Quan Zhuang, Jiang Zhu, Bo Peng, Yi Zhu, Ke Cheng, Yingzi Ming
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引用次数: 0

Abstract

Objectives: In kidney transplant recipients (KTRs), immune monitoring of peripheral lymphocyte subsets (PLS) reflects the real immune status and aids in the diagnosis of the occurrence and development of infectious diseases, including COVID-19. Exploring the PLS of COVID-19 pneumonia in KTRs is important.

Methods: In this study, a total of 103 KTRs were divided into mild pneumonia (MP) and severe pneumonia (SP) groups, as well as a stable group. The clinical information and PLS data were assessed via t or Mann-Whitney test and receiver operating curve analysis. Logistic regression was employed to identify the risk factors, and Spearman's correlation analysis was used to identify correlations.

Results: Lymphopenia is a common manifestation of COVID-19 in KTRs, and it is positively related to the severity of COVID-19 pneumonia. The CD3 + T-cell count had the highest AUC between the MP and the SP. Multiple PLS measures were found to be independent risk factors for COVID-19 pneumonia progression in KTRs.

Conclusions: This study revealed a robust correlation between PLS and severe COVID-19 pneumonia progression in KTRs. PLS monitoring could facilitate real-time diagnosis and therapy for infection, as well as timely and precisive adjustment of immunosuppression instructions, for KTRs with COVID-19.

肾移植受者外周血淋巴细胞亚群监测与COVID-19肺炎的相关性
目的:在肾移植受者(KTRs)中,外周血淋巴细胞亚群(PLS)的免疫监测反映了真实的免疫状态,有助于诊断包括COVID-19在内的感染性疾病的发生和发展。探讨冠状病毒肺炎在KTRs中的PLS具有重要意义。方法:本研究将103例KTRs分为轻度肺炎(MP)组、重度肺炎(SP)组和稳定组。通过t或Mann-Whitney检验和受试者工作曲线分析评估临床信息和PLS数据。危险因素采用Logistic回归分析,相关性采用Spearman相关分析。结果:淋巴细胞减少是冠状病毒肺炎的常见表现,与冠状病毒肺炎的严重程度呈正相关。CD3 + t细胞计数在MP和SP之间具有最高的AUC。多项PLS测量被发现是ktr患者COVID-19肺炎进展的独立危险因素。结论:本研究揭示了KTRs中PLS与COVID-19严重肺炎进展之间的相关性。PLS监测有助于对新冠病毒感染的KTRs进行实时诊断和治疗,及时、准确地调整免疫抑制指令。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Infectious Diseases
BMC Infectious Diseases 医学-传染病学
CiteScore
6.50
自引率
0.00%
发文量
860
审稿时长
3.3 months
期刊介绍: BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.
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