Sex-dependent behavioral alterations in BALB/c mouse bearing a non-CNS solid tumor

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-03-25 DOI:10.1016/j.bbr.2025.115556

Isaias Gutierrez-Leal, Luisa M. Onofre-Alvarado, Diana Caballero-Hernández, Ana L. Cantú-Ruiz, Moises A. Franco-Molina, Ricardo Gomez-Flores, Patricia Tamez-Guerra, Cristina Rodríguez-Padilla

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引用次数: 0

Abstract

Background

Peripheral tumors can alter the central nervous system activity leading to behavior alterations and cancer-related cognitive impairment (CRCI). Although commonly attributed to anti-cancer treatments, findings of CRCI in newly diagnosed cancer patients suggest that tumors alone may impair brain functions, including working memory and processing speed.

Methods

We assessed male and female mice behavior using a novel object recognition and a Y maze test along with the open field and burrowing tests. The tests were performed before and after tumor implantation (subcutaneous murine L5178Y-R lymphoma injection in the posterior hind limb), and through its progression to evaluate mobility, anxiety, motivation recognition, and spatial working memory.

Results

Male mice showed deficits in recognition memory, scoring a low novel object time exploration (42.26 % in males [p = 0.02] and 50.15 % [p = 0.53] in females). Spontaneous alternation was significantly impaired in both male (p = 0.01) and female (p = 0.03) mice. During tumor progression, only female mice showed decreased mobility in indicators such as average speed, mobility rate, and total distance in the open field test, as well as deficient burrowing activity, indicating a lack of motivation or sickness behavior. Our findings suggest that tumor burden is associated with behavioral alterations in a sex-dependent manner in a mouse model of lymphoma.

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携带非中枢神经系统实体瘤的BALB/c小鼠性别依赖的行为改变。

背景：外周肿瘤可改变中枢神经系统活动，导致行为改变和癌症相关认知障碍（CRCI）。虽然通常归因于抗癌治疗，但在新诊断的癌症患者中发现的CRCI表明，肿瘤本身可能损害大脑功能，包括工作记忆和处理速度。方法：采用一种新颖的物体识别和Y迷宫测试以及空地和挖洞测试来评估雄性和雌性小鼠的行为。在肿瘤植入前后（小鼠后肢皮下注射L5178Y-R淋巴瘤）进行测试，并通过其进展来评估活动能力、焦虑、动机识别和空间工作记忆。结果：雄性小鼠出现识别记忆缺陷，新物体时间探索得分低（雄性为42.26% [p = 0.02]，雌性为50.15% [p = 0.53]）。自发性交替在雄性和雌性小鼠中均明显受损（p = 0.01）。在肿瘤进展过程中，只有雌性小鼠在野外测试中表现出平均速度、移动率和总距离等指标的移动能力下降，以及挖洞活动不足，表明缺乏动力或疾病行为。我们的研究结果表明，在淋巴瘤小鼠模型中，肿瘤负荷以性别依赖的方式与行为改变相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.