Hydrogel Innovations in Biosensing: A New Frontier for Pancreatitis Diagnostics.

IF 3.8 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Prerna Sutar, Atharv Pethe, Piyush Kumar, Divya Tripathi, Dipak Maity
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引用次数: 0

Abstract

Pancreatitis is a prominent and severe type of inflammatory disorder that has grabbed a lot of scientific and clinical interest to prevent its onset. It should be detected early to avoid the development of serious complications, which occur due to long-term damage to the pancreas. The accurate measurement of biomarkers that are released from the pancreas during inflammation is essential for the detection and early treatment of patients with severe acute and chronic pancreatitis, but this is sub-optimally performed in clinically relevant practices, mainly due to the complexity of the procedure and the cost of the treatment. Clinically available tests for the early detection of pancreatitis are often time-consuming. The early detection of pancreatitis also relates to disorders of the exocrine pancreas, such as cystic fibrosis in the hereditary form and cystic fibrosis-like syndrome in the acquired form of pancreatitis, which are genetic disorders with symptoms that can be correlated with the overexpression of specific markers such as creatinine in biological fluids like urine. In this review, we studied how to develop a minimally invasive system using hydrogel-based biosensors, which are highly absorbent and biocompatible polymers that can respond to specific stimuli such as enzymes, pH, temperature, or the presence of biomarkers. These biosensors are helpful for real-time health monitoring and medical diagnostics since they translate biological reactions into quantifiable data. This paper also sheds light on the possible use of Ayurvedic formulations along with hydrogels as a treatment strategy. These analytical devices can be used to enhance the early detection of severe pancreatitis in real time.

生物传感中的水凝胶创新:胰腺炎诊断的新前沿。
胰腺炎是一种突出而严重的炎症性疾病,已经引起了许多科学和临床的兴趣,以预防其发病。它应该及早发现,以避免发展严重的并发症,这是由于长期损害胰腺。准确测量炎症期间胰腺释放的生物标志物对于严重急性和慢性胰腺炎患者的检测和早期治疗至关重要,但在临床相关实践中,这是次优的,主要是由于程序的复杂性和治疗的成本。临床上用于早期发现胰腺炎的测试通常很耗时。胰腺炎的早期发现也与外分泌胰腺疾病有关,如遗传性形式的囊性纤维化和获得性形式的囊性纤维化样综合征,这是一种遗传性疾病,其症状可能与尿等生物液体中特定标记物(如肌酐)的过度表达有关。在这篇综述中,我们研究了如何使用基于水凝胶的生物传感器开发一种微创系统,水凝胶是一种高吸收性和生物相容性的聚合物,可以响应特定的刺激,如酶、pH、温度或生物标志物的存在。这些生物传感器有助于实时健康监测和医学诊断,因为它们将生物反应转化为可量化的数据。本文还阐明了可能使用阿育吠陀配方连同水凝胶作为治疗策略。这些分析设备可用于提高重症胰腺炎的实时早期检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Bioengineering
Bioengineering Chemical Engineering-Bioengineering
CiteScore
4.00
自引率
8.70%
发文量
661
期刊介绍: Aims Bioengineering (ISSN 2306-5354) provides an advanced forum for the science and technology of bioengineering. It publishes original research papers, comprehensive reviews, communications and case reports. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. All aspects of bioengineering are welcomed from theoretical concepts to education and applications. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, four key features of this Journal: ● We are introducing a new concept in scientific and technical publications “The Translational Case Report in Bioengineering”. It is a descriptive explanatory analysis of a transformative or translational event. Understanding that the goal of bioengineering scholarship is to advance towards a transformative or clinical solution to an identified transformative/clinical need, the translational case report is used to explore causation in order to find underlying principles that may guide other similar transformative/translational undertakings. ● Manuscripts regarding research proposals and research ideas will be particularly welcomed. ● Electronic files and software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. ● We also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds. Scope ● Bionics and biological cybernetics: implantology; bio–abio interfaces ● Bioelectronics: wearable electronics; implantable electronics; “more than Moore” electronics; bioelectronics devices ● Bioprocess and biosystems engineering and applications: bioprocess design; biocatalysis; bioseparation and bioreactors; bioinformatics; bioenergy; etc. ● Biomolecular, cellular and tissue engineering and applications: tissue engineering; chromosome engineering; embryo engineering; cellular, molecular and synthetic biology; metabolic engineering; bio-nanotechnology; micro/nano technologies; genetic engineering; transgenic technology ● Biomedical engineering and applications: biomechatronics; biomedical electronics; biomechanics; biomaterials; biomimetics; biomedical diagnostics; biomedical therapy; biomedical devices; sensors and circuits; biomedical imaging and medical information systems; implants and regenerative medicine; neurotechnology; clinical engineering; rehabilitation engineering ● Biochemical engineering and applications: metabolic pathway engineering; modeling and simulation ● Translational bioengineering
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