Trajectories of Cognitive Change and Their Association with All-Cause Mortality Among Chinese Older Adults: Results from the Chinese Longitudinal Healthy Longevity Survey.

Abstract

The analysis of cognitive trajectories is relatively underexplored in China. Furthermore, most previous studies examining the association between cognitive function and mortality have been limited to cross-sectional perspectives. This study aims to identify distinct cognitive trajectories and the corresponding influencing factors and investigate the impact of these trajectories on all-cause mortality in Chinese older adults. A total of 6232 subjects aged 65 years and above were drawn from the Chinese Longitudinal Healthy Longevity Survey. Growth mixture models were utilized to identify different cognitive trajectories, while Cox proportional hazards models were used to examine the association between the cognitive trajectories and all-cause mortality after adjusting for covariates. Four cognitive trajectories were identified: rapid decline group, slow decline group, low-level stable group, and high-level stable group. Some factors such as age, sex, and marital status were significantly associated with trajectories. Compared to the high-level stable group, adjusted hazard ratios and 95% confidence intervals (CIs) for the all-cause mortality were 3.87 (95% CI: 3.35-4.48), 1.41 (95% CI: 1.24-1.59), and 1.37 (95% CI: 1.18-1.58) for the rapid decline group, the slow decline group, and the low-level stable group, respectively, indicating that these three groups had a higher mortality risk. In summary, these findings facilitate the development of targeted health promotion measures, which have implications for reducing the social and economic burdens of cognitive decline.