Effects of Feed Restriction on Growth Performance, Nutrient Utilisation, Biochemical Parameters, and the Caecum Microbiota and Metabolites in Rabbits.

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-03-14 DOI:10.3390/ani15060842

Qi Lu, Jixiao Qin, Shuanglong Xie, Rui Chen, Xu Wang, Yiqing Xu, Yiming Ban, Chengcheng Gao, Peiyao Li, Di Zhou, Xingzhou Tian

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引用次数: 0

Abstract

The main objective of this research was to observe the effects of feed restriction on caecum microbiota and metabolites in rabbits. Forty-eight male 8-week-old rabbits with similar body weights (1872.11 ± 180.85 g) were randomly assigned to two treatments according to completely randomized design: (1) the control group received ad libitum access to feed (AL), and (2) the treatment received 80% of the feed consumed by the control (FR). The results showed that FR did not differ (p > 0.05) for average daily weight gain or feed conversion ratio between the two groups. FR treatment led to a significant increase (p < 0.05) in acid detergent fibre apparent faecal digestibility, nitrogen digestibility and retention, and gross energy digestibility and retention. The FR treatment showed significantly (p < 0.05) lower blood triglycerides, creatinine, high-density lipoprotein cholesterol, malondialdehyde, and hydroxyl free radicals but significantly (p < 0.05) greater total antioxidant capacity and superoxide dismutase. The FR group presented greater (p < 0.05) Firmicutes and Ruminococcus abundances but a lower (p < 0.05) Akkermansiaceae abundance in the caecal content. Moreover, 222 differentiated metabolites were identified, and beta-alanine metabolism was the top enriched pathway. Collectively, FR can improve nutrient utilisation, lipid metabolism, antioxidant activity, caecum microbiota, and metabolites in rabbits.

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).