{"title":"Risk of Coronary Artery Calcification Based on Degree of Obesity and Age Group in Korean Adults: Analysis of Kangbuk Samsung Health Study Data.","authors":"Da-Eun Sung, Da-Youn Lee, Eun-Jung Rhee","doi":"10.1016/j.amjcard.2025.03.020","DOIUrl":null,"url":null,"abstract":"<p><p>This study examined the relationship between body mass index (BMI) and coronary artery calcification (CAC) in a large cohort of adults undergoing routine health evaluations, focusing particularly on the modifying role of age. We analyzed health data from 182,008 male employees and their family members in South Korea between 2010 and 2019, categorizing participants by BMI and age. CAC, a validated marker of subclinical atherosclerosis and a predictor of cardiovascular events, was measured via multidetector computed tomography. In unadjusted analyses, overweight and obese individuals exhibited a significantly higher risk of CAC compared to those with underweight BMI. After adjusting for potential confounding factors, obesity remained independently associated with an increased risk of CAC, while the association with overweight was no longer significant. Age strongly influenced this relationship; individuals aged 70 years or older demonstrated a markedly higher CAC risk, but obesity's association with CAC was significant only in those aged 60 years or younger. These findings indicate that obesity, even in the absence of metabolic abnormalities, contributes to an increased risk of atherosclerosis in younger individuals, challenging the concept of \"metabolically healthy obesity.\" In conclusion, our results underscore the importance of targeted cardiovascular risk assessments that consider both BMI and age, highlighting the need for early intervention in younger adults with elevated BMI to prevent atherosclerosis and suggesting a distinct risk profile in older adults.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.amjcard.2025.03.020","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
This study examined the relationship between body mass index (BMI) and coronary artery calcification (CAC) in a large cohort of adults undergoing routine health evaluations, focusing particularly on the modifying role of age. We analyzed health data from 182,008 male employees and their family members in South Korea between 2010 and 2019, categorizing participants by BMI and age. CAC, a validated marker of subclinical atherosclerosis and a predictor of cardiovascular events, was measured via multidetector computed tomography. In unadjusted analyses, overweight and obese individuals exhibited a significantly higher risk of CAC compared to those with underweight BMI. After adjusting for potential confounding factors, obesity remained independently associated with an increased risk of CAC, while the association with overweight was no longer significant. Age strongly influenced this relationship; individuals aged 70 years or older demonstrated a markedly higher CAC risk, but obesity's association with CAC was significant only in those aged 60 years or younger. These findings indicate that obesity, even in the absence of metabolic abnormalities, contributes to an increased risk of atherosclerosis in younger individuals, challenging the concept of "metabolically healthy obesity." In conclusion, our results underscore the importance of targeted cardiovascular risk assessments that consider both BMI and age, highlighting the need for early intervention in younger adults with elevated BMI to prevent atherosclerosis and suggesting a distinct risk profile in older adults.
期刊介绍:
Published 24 times a year, The American Journal of Cardiology® is an independent journal designed for cardiovascular disease specialists and internists with a subspecialty in cardiology throughout the world. AJC is an independent, scientific, peer-reviewed journal of original articles that focus on the practical, clinical approach to the diagnosis and treatment of cardiovascular disease. AJC has one of the fastest acceptance to publication times in Cardiology. Features report on systemic hypertension, methodology, drugs, pacing, arrhythmia, preventive cardiology, congestive heart failure, valvular heart disease, congenital heart disease, and cardiomyopathy. Also included are editorials, readers'' comments, and symposia.