Recent advances in nanoprecipitation: from mechanistic insights to applications in nanomaterial synthesis.

IF 2.9 3区 化学 Q3 CHEMISTRY, PHYSICAL
Soft Matter Pub Date : 2025-03-28 DOI:10.1039/d5sm00006h
Muzammil Kuddushi, Chiranjeevi Kanike, Ben Bin Xu, Xuehua Zhang
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引用次数: 0

Abstract

Nanoprecipitation is a versatile, low-energy technique for synthesizing nanomaterials through controlled precipitation, enabling precise tuning of material properties. This review offers a comprehensive and up-to-date perspective on nanoprecipitation, focusing on its role in nanoparticle synthesis and its adaptability in designing diverse nanostructures. The review begins with the foundational principles of nanoprecipitation, emphasizing the impact of key parameters such as flow rate, mixing approach, injection rate, and Reynolds number on nanomaterial characteristics. It also discusses the influence of physicochemical factors, including solvent choice, polymer type, and drug properties. Various nanoprecipitation configurations-batch, flash, and microfluidic are examined for their specific advantages in controlling particle size, morphology, and internal structure. The review further explores the potential of nanoprecipitation to create complex nanostructures, such as core-shell particles, Janus nanoparticles, and porous and semiconducting polymer nanoparticles. Applications in biomedicine and other fields highlight nanoprecipitation's promise as a sustainable and tunable method for fabricating advanced nanomaterials. Finally, the review identifies future directions, including scaling microfluidic techniques, expanding compatibility with hydrophilic compounds, and integrating machine learning to further enhance the development of nanoprecipitation.

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来源期刊
Soft Matter
Soft Matter 工程技术-材料科学:综合
CiteScore
6.00
自引率
5.90%
发文量
891
审稿时长
1.9 months
期刊介绍: Soft Matter is an international journal published by the Royal Society of Chemistry using Engineering-Materials Science: A Synthesis as its research focus. It publishes original research articles, review articles, and synthesis articles related to this field, reporting the latest discoveries in the relevant theoretical, practical, and applied disciplines in a timely manner, and aims to promote the rapid exchange of scientific information in this subject area. The journal is an open access journal. The journal is an open access journal and has not been placed on the alert list in the last three years.
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