Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2025-03-28 DOI:10.1111/echo.70135

Li Yu, Zurong Yang, Zhang Ming, Qichang Zhou, Shi Zeng

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引用次数: 0

Abstract

Purpose

Evaluating the biomechanical properties of the aorta is crucial for assessing cardiovascular risk and preventing disease progression. The aim of this study was to evaluate the biomechanical properties of the ascending aorta (AA) in severe obstructive sleep apnea syndrome (OSAS) patients with or without hypertension (HT) via velocity vector imaging (VVI).

Methods

A total of 68 patients with severe OSAS were selected, 35 of whom were included in the simple OSAS group and 33 of whom were included in the OSAS + HT group, and 40 volunteers without these two disorders who were taken as the control group. AA biomechanical properties, that is, AA longitudinal strain (ALS), AA circumferential strain (ACS), and fractional area change (FAC), were evaluated via VVI. Pulsed Doppler early transmitral peak flow velocity (E), early diastolic mitral annular velocity (e’), left ventricular (LV) global longitudinal strain (GLS), and the AA dimension (AD) were also measured.

Results

ALS (mean ± SD; 32.8% ± 11.9% and 19.7% ± 7.6% vs. 40.6% ± 15.6%, p = 0.006), ACS (mean ± SD; 11.8% ± 3.5% and 8.6% ± 2.7% vs. 16.5% ± 5.8%, p = 0.02), and FAC (mean ± SD; 21.0% ± 5.3% and 12.4% ± 3.8% vs. 32.8% ± 9.7%, p = 0.004) were significantly lower in the patient groups (OSAS and OSAS + HT, respectively) than in the control group. LV systolic and diastolic functions were also impaired in the patient groups. Compared with volunteers without OSAS and HT, these patients had a greater AD and E/e’ ratio and a lower GLS (p < 0.01). The aortic biomechanical properties were strongly correlated with the LV function and sleep parameters.

Conclusion

AA biomechanical properties are impaired in patients with severe OSAS, especially those with HT. Impairments in these aortic biomechanical properties are associated with diminished LV function and abnormal sleep parameters. This discovery may help clinicians identify and manage potential cardiovascular risks in OSAS patients. Further large-scale longitudinal studies are needed to confirm the potential predictive value of aortic events (e.g., aortic aneurysm or dissection) in patients with OSAS.

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重度阻塞性睡眠呼吸暂停综合征患者主动脉生物力学特性受损

目的评估主动脉的生物力学特性对评估心血管风险和预防疾病进展至关重要。采用速度矢量成像（VVI）技术评价伴有或不伴有高血压的严重阻塞性睡眠呼吸暂停综合征（OSAS）患者升主动脉（AA）的生物力学特性。方法选取68例重度OSAS患者，其中单纯OSAS组35例，OSAS + HT组33例。40名没有这两种疾病的志愿者作为对照组。通过VVI评估AA的生物力学性能，即AA纵向应变（ALS）、AA周向应变（ACS）和分数面积变化（FAC）。测量了脉冲多普勒早期透射峰血流速度(E)、舒张早期二尖瓣环速度（E’）、左室总纵应变（GLS）和左室直径（AD）。结果ALS (mean±SD；32.8%±11.9%和19.7%±7.6%比40.6%±15.6%,p = 0.006), ACS(平均数±标准差;11.8%±3.5%和8.6%±2.7%比16.5%±5.8%,p = 0.02)和FAC(平均数±标准差;OSAS组（21.0%±5.3%）和OSAS + HT组（12.4%±3.8%比32.8%±9.7%,p = 0.004）显著低于对照组。患者组左室收缩和舒张功能也受损。与没有OSAS和HT的志愿者相比，这些患者的AD和E/ E比值更高，GLS更低(p <；0.01)。主动脉生物力学特性与左室功能和睡眠参数密切相关。结论严重OSAS患者AA生物力学性能受损，尤其是合并HT患者。这些主动脉生物力学特性的损伤与左室功能减弱和睡眠参数异常有关。这一发现可能有助于临床医生识别和管理OSAS患者潜在的心血管风险。需要进一步的大规模纵向研究来证实OSAS患者主动脉事件（如主动脉瘤或夹层）的潜在预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.