Evaluation of Orexin-A, Adiponectin and Apelin-13 Serum Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-03-29 DOI:10.1002/jdn.70014

Serdar Avunduk, Ömer Başay, Süleyman Demir, Ayşen Çetin Kardeşler

{"title":"Evaluation of Orexin-A, Adiponectin and Apelin-13 Serum Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder","authors":"Serdar Avunduk, Ömer Başay, Süleyman Demir, Ayşen Çetin Kardeşler","doi":"10.1002/jdn.70014","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>This study investigates the role of orexin-a, adiponectin (HMWA) and apelin-13 serum levels in the etiopathogenesis of attention deficit hyperactivity disorder (ADHD), a neurodevelopmental disorder with unclear aetiology involving neuropathological, genetic and environmental factors.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study involved 37 children with ADHD and 35 healthy controls, aged 6–18 years, with no history of other physical or psychiatric illnesses and no psychotropic medication use in the last 6 months. Serum levels of orexin-a, adiponectin (HMWA) and apelin-13 were measured using enzyme-linked immunosorbent assay (ELISA). ADHD symptoms were assessed through Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5)–based clinical interviews, Conners Parent and Teacher Rating Scales and Wisconsin Card Sorting Test.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>No significant differences in serum orexin-a, adiponectin (HMWA) and apelin-13 levels were found between the ADHD and control groups. Additionally, there was no relationship between orexin-a, apelin-13 and adinopectin levels and ADHD symptoms and Wisconsin Card Sorting Test results. Analysis of adiponectin levels in preadolescent children aged 6–11, adjusting for age and BMI, revealed a statistically significant reduction in the ADHD group (<i>p</i> = 0.002).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results did not demonstrate any correlation between ADHD and the levels of orexin-a and apelin-13. However, the study revealed that children with ADHD, aged 6–11, exhibited decreased adiponectin concentrations. These results suggest that a decrease in serum adinopectin levels may be associated with ADHD in children.</p>\n </section>\n </div>","PeriodicalId":13914,"journal":{"name":"International Journal of Developmental Neuroscience","volume":"85 2","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jdn.70014","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective

This study investigates the role of orexin-a, adiponectin (HMWA) and apelin-13 serum levels in the etiopathogenesis of attention deficit hyperactivity disorder (ADHD), a neurodevelopmental disorder with unclear aetiology involving neuropathological, genetic and environmental factors.

Methods

The study involved 37 children with ADHD and 35 healthy controls, aged 6–18 years, with no history of other physical or psychiatric illnesses and no psychotropic medication use in the last 6 months. Serum levels of orexin-a, adiponectin (HMWA) and apelin-13 were measured using enzyme-linked immunosorbent assay (ELISA). ADHD symptoms were assessed through Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5)–based clinical interviews, Conners Parent and Teacher Rating Scales and Wisconsin Card Sorting Test.

Results

No significant differences in serum orexin-a, adiponectin (HMWA) and apelin-13 levels were found between the ADHD and control groups. Additionally, there was no relationship between orexin-a, apelin-13 and adinopectin levels and ADHD symptoms and Wisconsin Card Sorting Test results. Analysis of adiponectin levels in preadolescent children aged 6–11, adjusting for age and BMI, revealed a statistically significant reduction in the ADHD group (p = 0.002).

Conclusion

The results did not demonstrate any correlation between ADHD and the levels of orexin-a and apelin-13. However, the study revealed that children with ADHD, aged 6–11, exhibited decreased adiponectin concentrations. These results suggest that a decrease in serum adinopectin levels may be associated with ADHD in children.

查看原文本刊更多论文

注意缺陷多动障碍患儿血清Orexin-A、脂联素和Apelin-13水平的评价

目的探讨食欲素-a、脂联素（HMWA）和apelin-13血清水平在注意缺陷多动障碍（ADHD）发病中的作用。ADHD是一种病因不明的神经发育障碍，涉及神经病理、遗传和环境因素。方法选取37例ADHD患儿和35例健康对照，年龄6 - 18岁，既往无其他身体或精神疾病史，近6个月未使用精神药物。采用酶联免疫吸附法（ELISA）测定血清食欲素-a、脂联素（HMWA）和apelin-13水平。ADHD症状通过基于精神障碍诊断与统计手册-5 （DSM-5）的临床访谈、康纳斯家长与教师评定量表和威斯康星卡片分类测验进行评估。结果ADHD组与对照组血清orexin-a、脂联素（HMWA）、apelin-13水平无显著差异。此外，食欲素-a、apelin-13和adinopectin水平与ADHD症状和威斯康星卡片分类测试结果没有关系。分析6-11岁青春期前儿童的脂联素水平，调整年龄和BMI，发现ADHD组的脂联素水平有统计学意义的降低（p = 0.002）。结论ADHD与orexin-a、apelin-13水平无相关性。然而，研究显示6-11岁的ADHD儿童脂联素浓度下降。这些结果提示血清adinopectin水平的降低可能与儿童ADHD有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.