A Novel Porous Coating Method of Commercially Pure Titanium Using Silk Fibroin and UV Light for Biomedical Implant Applications

IF 3.9 3区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part A Pub Date : 2025-03-28 DOI:10.1002/jbm.a.37887

Olatunji Ajiteru, Kyu Young Choi, Fatma Nur Depboylu, Ji Seung Lee, Ok Joo Lee, Moon Sik Oh, Soon Hee Kim, Feza Korkusuz, Chan Hum Park

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引用次数: 0

Abstract

Surface coatings for titanium implants have been actively investigated using numerous materials to improve biocompatibility and osteointegration. This study developed a novel porous coating method for titanium implants; we coated commercially pure titanium (Cp-Ti) using the photocurable properties of methacrylated silk fibroin (SilMA). Surface morphologies and alloying chemistry after coating were investigated by scanning electron microscopy (SEM) and EDS, while the biocompatibility of the SilMA-coated Cp-Ti was evaluated by the CCK-8 and live/dead assays. With various SilMA concentrations, uniform and strong SilMA coatings were obtained by UV light for both thin and thick coating methods. A universal mechanical testing machine evaluated the mechanical properties of SilMA coating. The interface adhesive strength of the coating taken by advanced centrifugal measurement was enhanced as the SilMA concentration increased. Cell cytotoxicity test results for 1, 3, 5, and 7 days revealed no toxic behavior in human dermal fibroblast cells. Cells on the SilMA-coated Cp-Ti revealed a higher proliferation and survival rate than those on the titanium without coating. These results show that this versatile coating method offers a tightly adhered bioactive coating of silk fibroin on titanium implants, demonstrating the potential for a universal coating method for use in a wide range of biomedical applications.

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来源期刊

Journal of biomedical materials research. Part A 工程技术-材料科学：生物材料

CiteScore

10.40

自引率

2.00%

发文量

135

审稿时长

3.6 months

期刊介绍： The Journal of Biomedical Materials Research Part A is an international, interdisciplinary, English-language publication of original contributions concerning studies of the preparation, performance, and evaluation of biomaterials; the chemical, physical, toxicological, and mechanical behavior of materials in physiological environments; and the response of blood and tissues to biomaterials. The Journal publishes peer-reviewed articles on all relevant biomaterial topics including the science and technology of alloys,polymers, ceramics, and reprocessed animal and human tissues in surgery,dentistry, artificial organs, and other medical devices. The Journal also publishes articles in interdisciplinary areas such as tissue engineering and controlled release technology where biomaterials play a significant role in the performance of the medical device. The Journal of Biomedical Materials Research is the official journal of the Society for Biomaterials (USA), the Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Articles are welcomed from all scientists. Membership in the Society for Biomaterials is not a prerequisite for submission.