Systemic inflammation correlates with depression and lower quality of life in patients with hidradenitis suppurativa independent of disease severity

IF 1.8 4区 医学 Q3 DERMATOLOGY
Nikolaos Rotsiamis, Natalia Rompoti, Aikaterini Liakou, Andreas G Tsantes, Stefanos Bonovas, George Samonis, Petros Ioannou, Alexandra Mpakosi, Ioannis-Alexios Koumprentziotis, Lydia Tsamtsouri, Eleni Chatzidimitriou, Soultana Vladeni, Stamatis Gregoriou, Electra Nicolaidou, Alexander Katoulis, Evangelia Papadavid, Dimitrios Rigopoulos
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Abstract

Hidradenitis suppurativa (HS) is associated with a cumulative life course impairment and patients commonly present with signs of depression and anxiety. This study aimed to investigate the association between systemic inflammation, measured by laboratory markers, and psychological burden, evaluated using specific psychometric scores, in patients with HS. The study also evaluated the impact of treatment initiation on inflammatory biomarkers and psychometric scores. A prospective, observational, monocentric study was conducted on adult patients with HS of Hurley stage I, II and III, who were eligible for treatment initiation. Disease severity was assessed using the Hurley stage, and disease activity through the IHS4 scoring system. Laboratory evaluation of systemic inflammation included measurement of White Blood Cell count, Erythrocyte Sedimentation Rate (ESR) and C-reactive protein levels, at the study onset, right before treatment initiation, at 12 weeks and at 24 weeks following treatment onset. The impact of the disease on psychological status and overall quality of life was evaluated through psychometric scores. Our results indicate that systemic inflammation, reflected by laboratory inflammatory markers such as ESR, is associated with a higher probability of depression, loneliness and reduced quality of life independently of Hurley stage, severity score, and clinical characteristics such as gender and smoking status. Psychometric evaluation, including the presence of depression and loneliness in HS patients, independent of Hurley stage is advisable, especially in cases where serum inflammatory markers, such as ESR, are high.

化脓性扁桃体炎(HS)与累积性生活障碍有关,患者通常伴有抑郁和焦虑症状。本研究旨在探讨化脓性扁桃体炎患者的全身炎症(通过实验室标记物测量)与心理负担(通过特定心理测量评分评估)之间的关联。研究还评估了开始治疗对炎症生物标志物和心理评分的影响。这项前瞻性、观察性、单中心研究的对象是符合开始治疗条件的赫尔利分期 I、II 和 III 期成年 HS 患者。采用赫利分期评估疾病严重程度,采用 IHS4 评分系统评估疾病活动度。对全身炎症的实验室评估包括在研究开始时、开始治疗前、开始治疗后 12 周和 24 周测量白细胞计数、红细胞沉降率(ESR)和 C 反应蛋白水平。疾病对心理状态和整体生活质量的影响通过心理测量评分进行评估。我们的研究结果表明,实验室炎症指标(如血沉)所反映的全身炎症与抑郁、孤独和生活质量下降的概率较高有关,与赫利分期、严重程度评分以及临床特征(如性别和吸烟状况)无关。建议进行心理评估,包括 HS 患者是否存在抑郁和孤独感,而不受 Hurley 分期的影响,尤其是在血清炎症指标(如血沉)较高的情况下。
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来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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