Exploring drug-induced liver injury: comprehensive insights into mechanisms and management of hepatotoxic agents

IF 3.4 Q2 PHARMACOLOGY & PHARMACY

Future Journal of Pharmaceutical Sciences Pub Date : 2025-03-28 DOI:10.1186/s43094-025-00788-5

Ahmed K. Saleh, Thanaa A. El-Masry, Aya H. El-Kadem, Nada A. Ashour, Nageh A. El-Mahdy

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引用次数: 0

Abstract

Background

Drug-induced liver injury (DILI) is a significant adverse drug reaction, manifesting through a range of clinical presentations from mild liver enzyme to acute liver failure.

Main text

This review provides a comprehensive overview of DILI, emphasizing the differences between intrinsic and idiosyncratic DILI. The underlying molecular mechanisms, like mitochondrial dysfunction, oxidative stress, and immune-mediated responses, are discussed in detail. The epidemiology of DILI is explored through various retrospective and prospective studies, highlighting the role of specific medications and individual susceptibility factors. The review also addresses the challenges in diagnosing DILI and the impact on drug development and clinical practice.

Conclusion

DILI poses a significant clinical threat due to its potential for causing acute liver failure and associated mortality. To improve patient outcomes, further research is crucial to identify effective therapeutic interventions.

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探索药物性肝损伤：对肝毒性药物的机制和管理的全面见解

背景药物性肝损伤（DILI）是一种严重的药物不良反应，表现为从轻度肝酶反应到急性肝衰竭的一系列临床表现。正文本综述全面概述了药物性肝损伤，强调了内在性药物性肝损伤和特发性药物性肝损伤之间的差异。详细讨论了潜在的分子机制，如线粒体功能障碍、氧化应激和免疫介导的反应。通过各种回顾性和前瞻性研究探讨了 DILI 的流行病学，强调了特定药物和个人易感因素的作用。本综述还探讨了诊断 DILI 所面临的挑战以及对药物开发和临床实践的影响。为了改善患者的预后，进一步的研究对于确定有效的治疗干预措施至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

自引率

0.00%

发文量

审稿时长

23 weeks

期刊介绍： Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.