Adverse childhood experiences and trajectories of chronic diseases: A population-base longitudinal study

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-03-28 DOI:10.1016/j.puhe.2025.03.014

Guilan Xie , Jiajia Li , Ruiqi Wang , Lijun Pei , Xinming Song , Gong Chen

{"title":"Adverse childhood experiences and trajectories of chronic diseases: A population-base longitudinal study","authors":"Guilan Xie , Jiajia Li , Ruiqi Wang , Lijun Pei , Xinming Song , Gong Chen","doi":"10.1016/j.puhe.2025.03.014","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Adverse childhood experiences (ACEs) have far-reaching effects on health outcomes. This study aimed to evaluate the associations of ACEs with trajectories and number of chronic diseases.</div></div><div><h3>Study design</h3><div>Cohort study.</div></div><div><h3>Methods</h3><div>Participants aged 45 years or older of China Health and Retirement Longitudinal Study were included. Ten kinds of ACEs encountered before 17 years old were calculated. Number of chronic diseases were assessed by 14 kinds of self-reported or proxy-reported diagnosed chronic diseases. The associations of specific types and number of ACEs with trajectories and number of chronic diseases were analyzed with latent class trajectory model, multinomial Logistic regression, and general estimating equation.</div></div><div><h3>Results</h3><div>Four trajectories of chronic diseases were identified in 12157 participants. With the reference of low baseline and persistent growth trajectory, those encountered physical abuse, domestic violence, household mental illness, and parental death had higher risks of high baseline and transient growth trajectory, middle baseline and accelerated growth trajectory of chronic diseases (ORs = 1.18–1.65). Compared to those without ACEs, those with 1 and above kinds of ACEs had elevated risks of middle baseline and persistent growth, high baseline and transient growth trajectory, middle baseline and accelerated growth trajectory of chronic diseases (ORs = 1.15–2.71). Physical abuse, domestic violence, bullying, household mental illness, parental death, and exposure of 2 and above kinds of ACEs increased the number of chronic diseases (β = 0.09–0.62). Associations of ACEs with trajectories and number of chronic diseases were more salient in women than men.</div></div><div><h3>Conclusions</h3><div>Different types and number of ACEs were related to trajectories of chronic diseases, especially in women. Early, comprehensive, and joint actions should be taken to prevent chronic diseases from a life-course perspective.</div></div>","PeriodicalId":49651,"journal":{"name":"Public Health","volume":"242 ","pages":"Pages 256-263"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0033350625001313","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

Adverse childhood experiences (ACEs) have far-reaching effects on health outcomes. This study aimed to evaluate the associations of ACEs with trajectories and number of chronic diseases.

Study design

Cohort study.

Methods

Participants aged 45 years or older of China Health and Retirement Longitudinal Study were included. Ten kinds of ACEs encountered before 17 years old were calculated. Number of chronic diseases were assessed by 14 kinds of self-reported or proxy-reported diagnosed chronic diseases. The associations of specific types and number of ACEs with trajectories and number of chronic diseases were analyzed with latent class trajectory model, multinomial Logistic regression, and general estimating equation.

Results

Four trajectories of chronic diseases were identified in 12157 participants. With the reference of low baseline and persistent growth trajectory, those encountered physical abuse, domestic violence, household mental illness, and parental death had higher risks of high baseline and transient growth trajectory, middle baseline and accelerated growth trajectory of chronic diseases (ORs = 1.18–1.65). Compared to those without ACEs, those with 1 and above kinds of ACEs had elevated risks of middle baseline and persistent growth, high baseline and transient growth trajectory, middle baseline and accelerated growth trajectory of chronic diseases (ORs = 1.15–2.71). Physical abuse, domestic violence, bullying, household mental illness, parental death, and exposure of 2 and above kinds of ACEs increased the number of chronic diseases (β = 0.09–0.62). Associations of ACEs with trajectories and number of chronic diseases were more salient in women than men.

Conclusions

Different types and number of ACEs were related to trajectories of chronic diseases, especially in women. Early, comprehensive, and joint actions should be taken to prevent chronic diseases from a life-course perspective.

查看原文本刊更多论文

不良的童年经历和慢性病的发展轨迹：一项基于人口的纵向研究

目的不良童年经历对健康结局有深远影响。本研究旨在评估ace与慢性疾病的发展轨迹和数量的关系。研究设计：队列研究。方法纳入45岁及以上中国健康与退休纵向研究对象。计算了17岁前发生的10种ace。采用自我报告或代理报告的14种诊断慢性疾病来评估慢性疾病的数量。应用潜类轨迹模型、多项Logistic回归和一般估计方程分析ace的具体类型和数量与轨迹和慢性病数量的关系。结果在12157名参与者中确定了四种慢性疾病轨迹。在低基线和持续增长轨迹的参照下，遭受过身体虐待、家庭暴力、家庭精神疾病和父母死亡的儿童的慢性病高基线和短暂增长轨迹、中基线和加速增长轨迹的风险更高（or = 1.18-1.65）。与无ace组相比，1种及以上ace组慢性疾病中基线和持续生长、高基线和短暂生长轨迹、中基线和加速生长轨迹的风险升高（or = 1.15-2.71）。身体虐待、家庭暴力、欺凌、家庭精神疾病、父母死亡和暴露于2种及以上ace使慢性疾病人数增加（β = 0.09-0.62）。ace与慢性疾病轨迹和数量的关联在女性中比在男性中更为显著。结论ace的不同类型和数量与慢性疾病的发展轨迹有关，尤其是女性。应及早采取综合和联合行动，从生命历程的角度预防慢性病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.