Colorimetric detection of thiocyanate via inhibiting the peroxidase-like activity of Fe-modified porphyrinic metal-organic framework

IF 3.2 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Solid State Chemistry Pub Date : 2025-03-27 DOI:10.1016/j.jssc.2025.125345

Zhiqiang Zhou, Xiao Zhang, Chunying Chen, Liyun Yang

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Abstract

Monitoring thiocyanate (SCN⁻) levels is important for both food safety and the health of humans. In this study, a colorimetric strategy based on Fe-modified porphyrinic MOF (PCN-224-Fe) for SCN⁻ detection was developed. The insertion of Fe³⁺ to PCN-224 leads to the formation of Fe–N₄ structure and endows the nanoprobe with peroxidase-like activity, and colorless TMB is oxidized to blue oxTMB in the presence of H₂O₂. Based on the formation of Fe(SCN)₆³⁻, SCN⁻ can poison the active Fe–N₄ site, thus inhibiting the peroxidase-like activity of the sensor. The colorimetric linear concentration-response of PCN-224-Fe towards SCN⁻ is 0.1–1 μM and 1–20 μM with a limit detection of 44 nM and 0.41 μM, respectively. This approach has shown its sensing accuracy of SCN⁻ in milk and human urine samples with recoveries ranging from 96.49 % to 102.79 %, proving its practical application in real samples analysis.

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来源期刊

Journal of Solid State Chemistry 化学-无机化学与核化学

CiteScore

6.00

自引率

9.10%

发文量

848

审稿时长

25 days

期刊介绍： Covering major developments in the field of solid state chemistry and related areas such as ceramics and amorphous materials, the Journal of Solid State Chemistry features studies of chemical, structural, thermodynamic, electronic, magnetic, and optical properties and processes in solids.