Five new cantharidin derivatives from the insect Mylabris cichorii and their potential for the treatment of neuroinflammatory diseases

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-26 DOI:10.1016/j.tet.2025.134624

Ke-Ming Li , Wei-Fen Li , Madhu Babu Sura , Guangyi Yang , Yong-Xian Cheng

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引用次数: 0

Abstract

Five previously undescribed monoterpenoids, including two 1,2-dimethyl cantharimide-type derivatives (1 and 2), one 1-hydroxymethyl-2-methyl cantharimide-type derivative (3), and two 1-methyl cantharimide-type derivatives (4 and 5), were isolated from the whole bodies of Mylabris cichorii L. Their structures, including absolute configurations, were identified using 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Considering the role of cantharidin derivatives in anti-neuroinflammation, all the compounds were evaluated for their neuroinflammatory activities. Results showed that compound 2 ameliorated LPS-induced neuroinflammation and reduced oxidative stress by targeting mitochondria, thereby decreasing reactive oxygen species (ROS) and pro-inflammatory cytokines. This suggests that compound 2 may be useful in treating neuroinflammatory diseases.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.