Review on application and development of pharmacogenomics of adverse drug reactions

Hongyu Bi , Jun Zhu , Yuanxuan Cai , Xiaofang Shangguan , Zherui Chen , Maimoon Shihab Ahmed , Rui Huang
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引用次数: 0

Abstract

Adverse drug reactions (ADRs) are a significant public health issue, contributing substantially to patient morbidity and mortality. The growing accessibility of genomic technologies has greatly advanced our understanding of the genetics underlying ADRs. Pharmacogenomics, which investigates how genetic polymorphisms influence individual responses to drug therapy on a genome-wide scale, plays a pivotal role in this field. The article summarizes the relationship between ADRs and genes, outlines the current applications and advancements of pharmacogenomics in the prediction, diagnosis, prevention, regulation, and personalized treatment of ADRs, and reviews cutting-edge research methods and large-scale international studies. These insights aim to provide a reference for the future development of pharmacogenomics in ADR research.
药物不良反应药物基因组学研究进展与应用综述
药物不良反应(adr)是一个重要的公共卫生问题,是导致患者发病率和死亡率的重要因素。基因组技术的日益普及极大地促进了我们对adr遗传学基础的理解。药物基因组学研究基因多态性如何在全基因组范围内影响个体对药物治疗的反应,在这一领域发挥着关键作用。本文综述了adr与基因的关系,概述了药物基因组学在adr预测、诊断、预防、调控和个性化治疗等方面的应用现状和进展,并对前沿研究方法和大规模国际研究进行了综述。这些见解旨在为药物基因组学在药品不良反应研究中的未来发展提供参考。
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