Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine

Lin Yang , Liang Wang , Baofeng Yang , Yue Zhang
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Abstract

Mitochondria play a central role in cardiovascular diseases, primarily by providing cellular energy and facilitating various cardiac functions. Excessive fat accumulation, circadian rhythm disturbances, viral infections, and persistent inflammation can lead to myocarditis, fibrosis, and infarction, thereby exacerbating the progression of cardiovascular diseases. As essential organelles for energy production, mitochondria exhibit remarkable dynamic adaptability and can integrate diverse cellular signaling pathways, endowing myocardial cells with both bioenergetic and biosynthetic versatility. Consequently, targeting mitochondria for cardiovascular disease therapy has gained increasing attention and is applicable to various cardiovascular conditions. Numerous mitochondrial adaptive mechanisms, including dynamics, metabolic processes, and apoptosis regulation, have emerged as promising therapeutic targets. Nevertheless, contemporary investigations into mitochondrial biology have unveiled their intricate structural and functional characteristics, as well as their complex roles within cellular systems, which present obstacles to the clinical implementation of mitochondria-focused cardiovascular therapies. Recent studies have found that traditional Chinese medicine (TCM) possesses the potential to effectively address cardiovascular diseases while enhancing the structural integrity and functional capacity of mitochondria. This review aims to offer a comprehensive analysis of the modulatory effects of TCM on cardiac mitochondria and its therapeutic ramifications for cardiovascular conditions.
线粒体功能:中药靶向治疗心血管疾病的新方向
线粒体在心血管疾病中发挥核心作用,主要是通过提供细胞能量和促进各种心脏功能。过度脂肪积累、昼夜节律紊乱、病毒感染和持续炎症可导致心肌炎、纤维化和梗死,从而加剧心血管疾病的进展。线粒体作为能量产生的重要细胞器,具有显著的动态适应性,可以整合多种细胞信号通路,赋予心肌细胞生物能量和生物合成的多功能性。因此,靶向线粒体治疗心血管疾病已越来越受到关注,并适用于各种心血管疾病。许多线粒体适应机制,包括动力学、代谢过程和细胞凋亡调节,已经成为有希望的治疗靶点。然而,当代对线粒体生物学的研究已经揭示了它们复杂的结构和功能特征,以及它们在细胞系统中的复杂作用,这给以线粒体为重点的心血管治疗的临床实施带来了障碍。最近的研究发现,中药在提高线粒体结构完整性和功能能力的同时,具有有效治疗心血管疾病的潜力。本文旨在全面分析中药对心脏线粒体的调节作用及其对心血管疾病的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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