Association of echocardiographic pulmonary hypertension with all-cause mortality in hospitalized AECOPD patients

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2025-03-29 DOI:10.1016/j.ijcha.2025.101661

Zhiqi Zhao , Xue He , Ruoyan Xiong , Yanan Cui , Weiwei Meng , Jiankang Wu , Jiayu Wang , Rui Zhao , Huihui Zeng , Yan Chen

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引用次数: 0

Abstract

Background

Chronic obstructive pulmonary disease (COPD) often coexists with pulmonary hypertension (PH). However, whether pulmonary artery pressure (PAP) or even suspected PH assessed by echocardiography during acute exacerbation stage predicts mortality after discharge is unclear.

Methods

We conducted an retrospective study of hospitalized patients with acute exacerbation of COPD (AECOPD). Peak tricuspid regurgitation velocity (TRV) and additional variables were used to assess PH risk.

Results

Cox regression analysis showed that echocardiographic suspected PH was the independent risk factor for the significantly increased long-term mortality (adjusted HR 1.64; 95% CI 1.06–2.53) after discharge in AECOPD patients. Logistic regression analysis revealed a negative correlation between blood eosinophil (EOS) counts at admission and the prevalence of suspected PH (adjusted OR 0.18; 95% CI 0.04–0.89). Triple therapy (adjusted HR 0.18; 95% CI 0.05–0.61), neither LABA/ICS during stable stage was associated with a significant reduction in long-term mortality in hospitalized AECOPD patients with suspected PH.

Conclusion

Echocardiographic suspected PH was associated with adverse survival in hospitalized AECOPD patients. Low EOS counts at admission emerged as a potential biomarker for elevated estimated systolic PAP. Triple therapy during stable stage was associated with a significant reduction in long-term mortality in AECOPD patients with suspected PH.

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.