Factors influencing acceptance of RSV immunization for newborns among pregnant individuals: A mixed-methods study

IF 4.5 3区 医学 Q2 IMMUNOLOGY
Dominique Gagnon , Charlotte Gubany , Manale Ouakki , Benjamin Malo , Maude Paquette , Nicholas Brousseau , Jesse Papenburg , Eve Dubé
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引用次数: 0

Abstract

Background

Respiratory syncytial virus (RSV) is a major cause of respiratory infections and hospitalizations in Canadian infants. Recently, Health Canada approved two novel immunizing products: a vaccine given during pregnancy and a monoclonal antibody for infants. This study assessed knowledge, attitudes, and intentions regarding RSV and its prevention among pregnant individuals.

Methods

A mixed-methods study was conducted in Quebec from October to December 2023. Pregnant individuals were recruited through targeted Facebook advertisements. Data were collected in two phases: Phase 1 involved an online survey to assess knowledge of RSV, attitudes toward immunization, and intentions regarding both immunization products, followed by qualitative interviews in Phase 2 to explore factors impacting decision-making and preferences for RSV prevention. Survey data were analyzed using descriptive statistics; interview data were analyzed through thematic analysis.

Results

Among survey participants (n = 803), 68.4 % reported some knowledge of RSV. Intention for both immunization products was high, with 88.1 % of participants willing to receive the RSV vaccine during pregnancy and 92 %, to administer monoclonal antibodies to their infants. A majority (69 %) of participants preferred vaccination during pregnancy over monoclonal antibodies. The desire to protect their infant from severe RSV complications was a key motivating factor of acceptance of new RSV immunizing products. Other key determinants included vaccine safety, efficacy, and recommendations by healthcare providers. Qualitative interviews (n = 25) highlighted safety concerns of expectant parents about these new products. The importance of clear and evidence-based recommendations by healthcare providers was also emphasized.

Conclusions

Pregnant individuals demonstrated a high level of interest in RSV immunization for infants, whether with vaccination during pregnancy or with monoclonal antibodies. Recommendations by healthcare providers and availability of information on the safety and efficacy of these new products will be key to move from intention to action.
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来源期刊
Vaccine
Vaccine 医学-免疫学
CiteScore
8.70
自引率
5.50%
发文量
992
审稿时长
131 days
期刊介绍: Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.
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