Lower limb deformity and gait deviations of osteogenesis imperfecta

IF 2.2 3区医学 Q3 NEUROSCIENCES

Gait & posture Pub Date : 2025-03-29 DOI:10.1016/j.gaitpost.2025.03.023

Yuanhao Liang , Shichen Qi , Tinghan Xu , Lin Feng , Eric Hiu Kwong Yeung , Rong He , Shijie Yin , Zhou Yapeng , Peikai Chen , Michael Kai-Tsun To , Yong Hu

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引用次数: 0

Abstract

Background

Osteogenesis imperfecta is a rare genetic disorder characterized by complex lower limb deformities, resulting in various gait limitations. This study aimed to (1) investigate the incidence and association between radiographic changes and gait impairment; (2) propose a lower limb deformity index to quantify deformity severity as well as gait performance.

Methods

Bilateral X-ray images and 3D gait analysis results were assessed retrospectively from 48 patients with osteogenesis imperfecta. Multivariate linear regression was used to investigate the contribution of each deformity to gait performance. Eight scoring approaches of the proposed index, calculated from radiographic changes, were evaluated by their linear relationship to gait deviation.

Results

Patients with osteogenesis imperfecta had high incidence of anterolateral bowing of femur, and anteromedial bowing of tibia, along with abducted hip, varus knee, hip flexion and ankle dorsiflexion deformities. Their maximum joint kinematics and kinetics were less than healthy controls, which was consistent with their major deformities. However, multivariate linear regression indicated a limited contribution from each deformity to gait deviation (only mechanical axis deviation out of 14 radiographic measures showed significance). Remarkably, our proposed index presented a significant linear correlation to gait deviation (Correlation coefficient: −0.650; R square: 0.423; F value: 33.719, p < 0.001).

Conclusions

This study preliminary demonstrated the association between lower limb deformities and gait deviations of patients with osteogenesis imperfecta and proposed a lower limb deformity index to quantify the deformity severity that reflects gait performance.

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来源期刊

Gait & posture 医学-神经科学

CiteScore

4.70

自引率

12.50%

发文量

616

审稿时长

6 months

期刊介绍： Gait & Posture is a vehicle for the publication of up-to-date basic and clinical research on all aspects of locomotion and balance. The topics covered include: Techniques for the measurement of gait and posture, and the standardization of results presentation; Studies of normal and pathological gait; Treatment of gait and postural abnormalities; Biomechanical and theoretical approaches to gait and posture; Mathematical models of joint and muscle mechanics; Neurological and musculoskeletal function in gait and posture; The evolution of upright posture and bipedal locomotion; Adaptations of carrying loads, walking on uneven surfaces, climbing stairs etc; spinal biomechanics only if they are directly related to gait and/or posture and are of general interest to our readers; The effect of aging and development on gait and posture; Psychological and cultural aspects of gait; Patient education.